Zhang Qinqin, Lee Cecilia S, Chao Jennifer, Chen Chieh-Li, Zhang Thomas, Sharma Utkarsh, Zhang Anqi, Liu Jin, Rezaei Kasra, Pepple Kathryn L, Munsen Richard, Kinyoun James, Johnstone Murray, Van Gelder Russell N, Wang Ruikang K
University of Washington, Department of Bioengineering, 3720 15th Ave NE, Seattle, WA 98195, USA.
University of Washington, Department of Ophthalmology, 325 Ninth Avenue, Seattle, WA 98104, USA.
Sci Rep. 2016 Feb 25;6:22017. doi: 10.1038/srep22017.
Optical coherence tomography angiography (OCTA) allows for the evaluation of functional retinal vascular networks without a need for contrast dyes. For sophisticated monitoring and diagnosis of retinal diseases, OCTA capable of providing wide-field and high definition images of retinal vasculature in a single image is desirable. We report OCTA with motion tracking through an auxiliary real-time line scan ophthalmoscope that is clinically feasible to image functional retinal vasculature in patients, with a coverage of more than 60 degrees of retina while still maintaining high definition and resolution. We demonstrate six illustrative cases with unprecedented details of vascular involvement in retinal diseases. In each case, OCTA yields images of the normal and diseased microvasculature at all levels of the retina, with higher resolution than observed with fluorescein angiography. Wide-field OCTA technology will be an important next step in augmenting the utility of OCT technology in clinical practice.
光学相干断层扫描血管造影（OCTA）无需使用造影剂就能评估视网膜功能血管网络。对于视网膜疾病的精密监测和诊断，能够在单幅图像中提供视网膜血管系统的宽视野和高清晰度图像的OCTA是理想之选。我们报告了一种通过辅助实时线扫描检眼镜进行运动跟踪的OCTA，它在临床上对患者功能性视网膜血管成像切实可行，可覆盖超过60度的视网膜，同时仍能保持高清晰度和分辨率。我们展示了六个具有前所未有的视网膜疾病血管受累细节的典型病例。在每个病例中，OCTA都能生成视网膜各层正常和病变微血管的图像，分辨率高于荧光素血管造影。宽视野OCTA技术将是增强OCT技术在临床实践中效用的重要下一步。
