视网膜色素变性干细胞治疗的最新进展
Recent advances of stem cell therapy for retinitis pigmentosa.
作者信息
He Yuxi, Zhang Yan, Liu Xin, Ghazaryan Emma, Li Ying, Xie Jianan, Su Guanfang
机构信息
Department of Ophthalmology, Second Hospital, Jilin University, Ziqiang Street No. 218, Changchun 130041, Jilin, China.
出版信息
Int J Mol Sci. 2014 Aug 20;15(8):14456-74. doi: 10.3390/ijms150814456.
Abstract
Retinitis pigmentosa (RP) is a group of inherited retinal disorders characterized by progressive loss of photoreceptors and eventually leads to retina degeneration and atrophy. Until now, the exact pathogenesis and etiology of this disease has not been clear, and many approaches for RP therapies have been carried out in animals and in clinical trials. In recent years, stem cell transplantation-based attempts made some progress, especially the transplantation of bone marrow-derived mesenchymal stem cells (BMSCs). This review will provide an overview of stem cell-based treatment of RP and its main problems, to provide evidence for the safety and feasibility for further clinical treatment.
摘要
视网膜色素变性（RP）是一组遗传性视网膜疾病，其特征是光感受器逐渐丧失，最终导致视网膜变性和萎缩。到目前为止，这种疾病的确切发病机制和病因尚不清楚，并且已经在动物和临床试验中开展了许多针对RP的治疗方法。近年来，基于干细胞移植的尝试取得了一些进展，尤其是骨髓间充质干细胞（BMSC）的移植。本综述将概述基于干细胞治疗RP及其主要问题，为进一步临床治疗的安全性和可行性提供依据。
相似文献
1
Recent advances of stem cell therapy for retinitis pigmentosa.视网膜色素变性干细胞治疗的最新进展
Int J Mol Sci. 2014 Aug 20;15(8):14456-74. doi: 10.3390/ijms150814456.
2
Recent advances in treatment of retinitis pigmentosa.视网膜色素变性治疗的最新进展。
Curr Stem Cell Res Ther. 2015;10(3):258-65. doi: 10.2174/1574888x09666141027103552.
3
Stem cell transplantation as a progressing treatment for retinitis pigmentosa.干细胞移植作为一种治疗视网膜色素变性的进展性疗法。
Cell Tissue Res. 2022 Feb;387(2):177-205. doi: 10.1007/s00441-021-03551-3. Epub 2022 Jan 10.
4
Bone marrow-derived stem cells preserve cone vision in retinitis pigmentosa.骨髓源性干细胞可保留视网膜色素变性患者的视锥细胞视觉。
J Clin Invest. 2004 Sep;114(6):755-7. doi: 10.1172/JCI22930.
5
Mesenchymal Stem Cell-Based Therapy for Retinal Degenerative Diseases: Experimental Models and Clinical Trials.基于间充质干细胞的视网膜退行性疾病治疗：实验模型与临床试验。
Cells. 2021 Mar 7;10(3):588. doi: 10.3390/cells10030588.
6
Treatment with Stem Cells from Human Exfoliated Deciduous Teeth and Their Derived Conditioned Medium Improves Retinal Visual Function and Delays the Degeneration of Photoreceptors.人脱落乳牙干细胞及其衍生条件培养基治疗可改善视网膜视觉功能并延缓光感受器变性。
Stem Cells Dev. 2019 Nov 15;28(22):1514-1526. doi: 10.1089/scd.2019.0158. Epub 2019 Nov 4.
7
Long-term safety of human retinal progenitor cell transplantation in retinitis pigmentosa patients.人视网膜祖细胞移植治疗色素性视网膜炎患者的长期安全性。
Stem Cell Res Ther. 2017 Sep 29;8(1):209. doi: 10.1186/s13287-017-0661-8.
8
Retinitis Pigmentosa: From Pathomolecular Mechanisms to Therapeutic Strategies.视网膜色素变性：从病理分子机制到治疗策略
Medicina (Kaunas). 2024 Jan 22;60(1):189. doi: 10.3390/medicina60010189.
9
Intravitreal autologous mesenchymal stem cell transplantation: a non-randomized phase I clinical trial in patients with retinitis pigmentosa.玻璃体内自体间充质干细胞移植：一项针对色素性视网膜炎患者的非随机 I 期临床试验。
Stem Cell Res Ther. 2021 Jan 9;12(1):52. doi: 10.1186/s13287-020-02122-7.
10
[Research progress of treatment strategies for retinitis pigmentosa].[视网膜色素变性治疗策略的研究进展]
Zhonghua Yan Ke Za Zhi. 2017 Feb 11;53(2):148-153. doi: 10.3760/cma.j.issn.0412-4081.2017.02.015.
引用本文的文献
1
Genetic Therapies for Retinitis Pigmentosa: Current Breakthroughs and Future Directions.视网膜色素变性的基因治疗：当前突破与未来方向
J Clin Med. 2025 Aug 11;14(16):5661. doi: 10.3390/jcm14165661.
2
Regenerative mechanisms of stem cells and their clinical applications for degenerative eye diseases.干细胞的再生机制及其在退行性眼病中的临床应用。
J Res Med Sci. 2024 Jul 30;29:42. doi: 10.4103/jrms.jrms_358_23. eCollection 2024.
3
Innovative approaches to treatment of eye diseases: advances in stem cell therapy use in ophthalmology.眼科疾病治疗的创新方法：眼科领域干细胞疗法的进展
Int Ophthalmol. 2025 Mar 22;45(1):113. doi: 10.1007/s10792-025-03493-7.
4
Efficacy and safety of minocycline in retinitis pigmentosa: a prospective, open-label, single-arm trial.米诺环素治疗视网膜色素变性的疗效与安全性：一项前瞻性、开放标签、单臂试验。
Signal Transduct Target Ther. 2024 Dec 4;9(1):339. doi: 10.1038/s41392-024-02037-2.
5
Nanotechnology in retinal diseases: From disease diagnosis to therapeutic applications.视网膜疾病中的纳米技术：从疾病诊断到治疗应用。
Biophys Rev (Melville). 2024 Nov 5;5(4):041305. doi: 10.1063/5.0214899. eCollection 2024 Dec.
6
The New Era of Therapeutic Strategies for the Management of Retinitis Pigmentosa: A Narrative Review of the Pathomolecular Mechanism for Gene Therapies.视网膜色素变性治疗策略的新时代：基因治疗病理分子机制的叙述性综述
Cureus. 2024 Aug 13;16(8):e66814. doi: 10.7759/cureus.66814. eCollection 2024 Aug.
7
Bone Marrow-derived Mesenchymal Stem Cell Therapy in Retinitis Pigmentosa.骨髓源性间充质干细胞疗法治疗视网膜色素变性
Curr Stem Cell Res Ther. 2025;20(4):421-433. doi: 10.2174/011574888X293265240311120103.
8
Retinitis Pigmentosa: From Pathomolecular Mechanisms to Therapeutic Strategies.视网膜色素变性：从病理分子机制到治疗策略
Medicina (Kaunas). 2024 Jan 22;60(1):189. doi: 10.3390/medicina60010189.
9
The New Era of Therapeutic Strategies for the Treatment of Retinitis Pigmentosa: A Narrative Review of Pathomolecular Mechanisms for the Development of Cell-Based Therapies.视网膜色素变性治疗策略的新时代：基于细胞疗法发展的病理分子机制的叙述性综述
Biomedicines. 2023 Sep 28;11(10):2656. doi: 10.3390/biomedicines11102656.
10
Stem cell therapy for inherited retinal diseases: a systematic review and meta-analysis.干细胞疗法治疗遗传性视网膜疾病：系统评价和荟萃分析。
Stem Cell Res Ther. 2023 Oct 5;14(1):286. doi: 10.1186/s13287-023-03526-x.
本文引用的文献
1
The promising potential of menstrual stem cells for antenatal diagnosis and cell therapy.月经干细胞在产前诊断和细胞治疗方面的巨大潜力。
Front Immunol. 2014 May 19;5:205. doi: 10.3389/fimmu.2014.00205. eCollection 2014.
2
Regenerative medicine for the kidney: renotropic factors, renal stem/progenitor cells, and stem cell therapy.肾脏再生医学：促肾因子、肾干/祖细胞与干细胞疗法
Biomed Res Int. 2014;2014:595493. doi: 10.1155/2014/595493. Epub 2014 May 8.
3
Isolation, expansion and characterisation of mesenchymal stem cells from human bone marrow, adipose tissue, umbilical cord blood and matrix: a comparative study.从人骨髓、脂肪组织、脐血和基质中分离、扩增和鉴定间充质干细胞：一项比较研究。
Cytotechnology. 2015 Oct;67(5):793-807. doi: 10.1007/s10616-014-9718-z. Epub 2014 May 6.
4
Gene therapy in the rd6 mouse model of retinal degeneration.视网膜变性 rd6 鼠模型中的基因治疗。
Adv Exp Med Biol. 2014;801:711-8. doi: 10.1007/978-1-4614-3209-8_89.
5
The past, present and future of stem cell clinical trials for ALS.肌萎缩侧索硬化症干细胞临床试验的过去、现在与未来。
Exp Neurol. 2014 Dec;262 Pt B:127-37. doi: 10.1016/j.expneurol.2014.02.021. Epub 2014 Mar 6.
6
Advances in gene therapy technologies to treat retinitis pigmentosa.治疗视网膜色素变性的基因治疗技术进展。
Clin Ophthalmol. 2014;8:127-36. doi: 10.2147/OPTH.S38041. Epub 2013 Dec 24.
7
The isolation and cultivation of bone marrow stem cells and evaluation of differences for neural-like cells differentiation under the induction with neurotrophic factors.骨髓干细胞的分离培养及其在神经营养因子诱导下向神经样细胞分化差异的评价。
Cytotechnology. 2014 Dec;66(6):1007-19. doi: 10.1007/s10616-013-9654-3. Epub 2014 Jan 1.
8
Isolation of adipose tissue mesenchymal stem cells without tissue destruction: a non-enzymatic method.无组织破坏的脂肪组织间充质干细胞分离：一种非酶法。
Tissue Cell. 2014 Feb;46(1):54-8. doi: 10.1016/j.tice.2013.11.002. Epub 2013 Nov 12.
9
Efficient Production of Photoreceptor Precursor Cells from Human Embryonic Stem Cells.从人类胚胎干细胞高效生产光感受器前体细胞。
Methods Mol Biol. 2016;1307:357-69. doi: 10.1007/7651_2013_57.
10
Stem cells in plastic surgery: a review of current clinical and translational applications.整形外科学中的干细胞：当前临床及转化应用综述
Arch Plast Surg. 2013 Nov;40(6):666-75. doi: 10.5999/aps.2013.40.6.666. Epub 2013 Nov 8.
Zotero 插件