Perviz Sadia, Khan Haroon, Pervaiz Aini
Department of Pharmacy, Abdul Wali Khan University Mardan Mardan, Pakistan.
Front Pharmacol. 2016 Feb 15;7:28. doi: 10.3389/fphar.2016.00028. eCollection 2016.
Depression is a heterogeneous mood disorder that has been classified and treated in a variety of ways. Although, a number of synthetic drugs are being used as standard treatment for clinically depressed patients, but they have adverse effects that can compromise the therapeutic treatments and patient's compliance. Unlike, synthetic medications, herbal medicines are widely used across the globe due to their wide applicability and therapeutic efficacy associated with least side effects, which in turn has initiated the scientific research regarding the antidepressant activity. This review is mostly based on the literature of the last decade, aimed at exploring the preclinical profile of plant-based alkaloids (the abundant secondary metabolite) as an emerging therapy for depression.
抑郁症是一种异质性情绪障碍，有多种分类和治疗方式。尽管目前有多种合成药物被用作临床抑郁症患者的标准治疗药物，但它们存在不良反应，可能会影响治疗效果和患者的依从性。与合成药物不同，草药因其广泛的适用性、治疗功效以及最小的副作用而在全球范围内广泛使用，这反过来引发了关于其抗抑郁活性的科学研究。本综述主要基于过去十年的文献，旨在探索植物生物碱（丰富的次生代谢产物）作为一种新兴抑郁症治疗方法的临床前概况。
