Loria Melissa J, Ali Zulfiqar, Abe Naohito, Sufka Kenneth J, Khan Ikhlas A
Departments of Psychology, University of Mississippi, MS 38677, USA.
National Center for Natural Products Research, University of Mississippi, MS 38677, USA.
J Ethnopharmacol. 2014 Aug 8;155(1):731-5. doi: 10.1016/j.jep.2014.06.007. Epub 2014 Jun 12.
Broad historical and current uses in addition to diverse activity on CNS targets may make Sceletium tortuosum a useful therapeutic in a variety of clinical settings. This study sought to more broadly characterize activity of Sceletium tortuosum and mesembrine in a number of common, rodent-based assays that model nociception, depression, anxiety, ataxia, and abuse liability.
Male Sprague-Dawley were administered Sceletium tortuosum extract products and behavioral responses were evaluated in the conditioned place preference (CPP), hot plate, forced swim, elevated plus, and rotarod tests.
Sceletium tortuosum does not cause preference or aversion in CPP. Mesembrine appears to have analgesic properties without abuse liabilities or ataxia. The Sceletium tortuosum fraction has antidepressant properties but does produce ataxia. The ataxia may limit its usefulness as an antidepressant unless the antidepressant activity is associated with one constituent and the ataxia is associated with a separate constituent.
除了对中枢神经系统靶点具有多种活性外，Sceletium tortuosum广泛的历史和当前用途可能使其在多种临床环境中成为一种有用的治疗药物。本研究旨在通过一些常见的、基于啮齿动物的实验，更广泛地描述Sceletium tortuosum和美鼠李碱在模拟伤害感受、抑郁、焦虑、共济失调和药物滥用倾向方面的活性。
给雄性斯普拉格-道利大鼠施用Sceletium tortuosum提取物产品，并在条件性位置偏爱（CPP）、热板、强迫游泳、高架十字迷宫和转棒试验中评估行为反应。
Sceletium tortuosum在CPP中不会引起偏爱或厌恶。美鼠李碱似乎具有镇痛特性，无药物滥用倾向或共济失调。Sceletium tortuosum组分具有抗抑郁特性，但会产生共济失调。除非抗抑郁活性与一种成分相关，而共济失调与另一种成分相关，否则共济失调可能会限制其作为抗抑郁药的用途。
