Richardson Elizabeth J, Brooks Larry G, Richards J Scott, Bombardier Charles H, Barber Jason, Tate Denise, Forchheimer Martin B, Fann Jesse R
a Department of Physical Medicine and Rehabilitation , University of Alabama at Birmingham , Birmingham , AL , USA.
b Department of Rehabilitation Medicine , University of Miami , Miami , Florida , USA.
J Spinal Cord Med. 2016 Sep;39(5):535-43. doi: 10.1080/10790268.2016.1151145. Epub 2016 Mar 4.
To examine the association of neuropathic and nociceptive pain severity and interference with quality of life (QoL) in persons with spinal cord injury (SCI) who underwent a randomized controlled 12-week trial of an antidepressant to treat depression. A secondary objective was to assess the effect of changes in pain on mobility and physical independence.
Multivariable ANCOVA models controlling for relevant demographic covariates, treatment condition, and baseline pain and QoL were used.
Six rehabilitation centers.
Of the 133 persons who were randomized into the trial, 108 provided pain severity and interference ratings through follow-up.
Not applicable.
The Satisfaction with Life Scale and the physical and mental component summary scores of the 12-Item Short-Form Health Survey (SF-12). Secondary outcome measures included the mobility and physical independence subscales of the Craig Handicap Assessment and Reporting Technique (CHART).
Broadly, few associations between pain and QoL were evident. Results revealed relationships between lower baseline nociceptive pain interference and higher satisfaction with life and mental health-related QoL at 12 weeks. Similarly, lower neuropathic pain interference was associated with change in physical independence, but unrelated to mobility.
Pain interference over time may be differentially related to QoL outcomes based on the type of pain following SCI, but overall, there were no extensive relationships between pain and QoL in this sample of depressed persons with SCI.
在脊髓损伤（SCI）患者中，这些患者参加了一项为期12周的治疗抑郁症的抗抑郁药随机对照试验，研究神经性疼痛和伤害性疼痛的严重程度及其对生活质量（QoL）的干扰之间的关联。次要目的是评估疼痛变化对活动能力和身体独立性的影响。
使用多变量协方差分析模型，控制相关人口统计学协变量、治疗条件以及基线疼痛和生活质量。
六个康复中心。
在随机分组进入试验的133人中，108人在随访期间提供了疼痛严重程度和干扰评分。
不适用。
生活满意度量表以及12项简短健康调查问卷（SF-12）的身体和心理成分汇总得分。次要结果测量包括克雷格障碍评估和报告技术（CHART）的活动能力和身体独立性子量表。
总体而言，疼痛与生活质量之间几乎没有明显关联。结果显示，较低的基线伤害性疼痛干扰与12周时较高的生活满意度和与心理健康相关的生活质量之间存在关联。同样，较低的神经性疼痛干扰与身体独立性的变化有关，但与活动能力无关。
随着时间的推移，疼痛干扰可能根据脊髓损伤后的疼痛类型与生活质量结果存在不同的关联，但总体而言，在这个患有脊髓损伤的抑郁症患者样本中，疼痛与生活质量之间没有广泛的关联。
