Gibbs Katie, Beaufort Andrew, Stein Adam, Leung Tung Ming, Sison Cristina, Bloom Ona
1The Feinstein Institute for Medical Research, New York, USA.
2Department of Physical Medicine and Rehabilitation, Northwell Health, New York, USA.
Spinal Cord Ser Cases. 2019 Apr 15;5:32. doi: 10.1038/s41394-019-0178-8. eCollection 2019.
Traumatic spinal cord injury (SCI) triggers complex changes that can negatively impact health and quality of life. The International SCI Data Sets were developed to enable more comparable data collection on the complex sequelae of SCI across studies. This should facilitate progress in mechanistic understanding and improving treatments of SCI.
Prospective observational pilot study.
To collect data on pain symptoms and quality of life (QoL) in adults living with chronic SCI.
Academic medical center, New York, USA.
The International SCI Basic Pain and Qol Data Sets were used to collect data from participants with chronic SCI ( = 31) at 2 study visits held 6 months apart. The QoL Data Set was also used to collect data from able-bodied persons of similar age and gender distribution ( = 28).
Most participants with SCI had multiple types and locations of pain problems at both study visits, despite reported being treated for pain. At both visits, the worst pain problem type was nociceptive, followed by neuropathic, which was typically rated of higher intensity. QoL scores were significantly lower across all domains of the data set in persons with SCI than able-bodied persons. Persons with pain tended to have lower QoL scores, although this trend was not significant.
This study demonstrates the presence, complexity and stability of pain symptoms refractory to treatment and lower quality of life ratings in persons with chronic SCI.
Grants from the Craig H. Neilsen Foundation, New York Empire Clinical Research Program, New York State Spinal Cord Injury Research Board.
创伤性脊髓损伤（SCI）会引发复杂的变化，对健康和生活质量产生负面影响。国际脊髓损伤数据集的开发旨在使不同研究中关于脊髓损伤复杂后遗症的数据收集更具可比性。这应有助于在对脊髓损伤的机制理解和改善治疗方面取得进展。
前瞻性观察性试点研究。
收集慢性脊髓损伤成年患者的疼痛症状和生活质量（QoL）数据。
美国纽约的学术医疗中心。
使用国际脊髓损伤基本疼痛和生活质量数据集，在相隔6个月的2次研究访视中收集慢性脊髓损伤参与者（n = 31）的数据。生活质量数据集还用于收集年龄和性别分布相似的健全人（n = 28）的数据。
尽管报告接受过疼痛治疗，但大多数脊髓损伤参与者在两次研究访视时都有多种类型和部位的疼痛问题。在两次访视中，最严重的疼痛问题类型是伤害性疼痛，其次是神经性疼痛，神经性疼痛通常强度更高。脊髓损伤患者在数据集所有领域的生活质量得分均显著低于健全人。有疼痛的患者往往生活质量得分较低，尽管这一趋势并不显著。
本研究表明慢性脊髓损伤患者存在难以治疗的疼痛症状、疼痛症状的复杂性和稳定性以及较低的生活质量评分。
克雷格·H·尼尔森基金会、纽约帝国临床研究项目、纽约州脊髓损伤研究委员会提供的资助。
