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影响头部非黑色素瘤皮肤癌Mohs显微外科手术修复方式选择的因素。

Factors affecting choice of repair in Mohs micrographic surgery for non-melanoma skin cancer of the head.

作者信息

Thomas Charlotte L, Lam Alvin, Lam Janice, Paver Robert, Storey Leslie, Fernandez-Peñas Pablo

机构信息

Skin and Cancer Foundation Australia, Sydney, New South Wales, Australia.

Sydney Medical School, University of Sydney, Sydney, New South Wales, Australia.

出版信息

Australas J Dermatol. 2017 Aug;58(3):189-193. doi: 10.1111/ajd.12453. Epub 2016 Feb 24.

Abstract

BACKGROUND/OBJECTIVES: In Mohs micrographic surgery (MMS) the dermatologist serves as surgeon, pathologist and reconstructive surgeon. Analysis of the factors that play a part in determining defect size and closure type may result in better patient outcomes. The objective was to identify factors contributing to the defect size and closure method employed in MMS.

METHODS

Retrospective analysis of all MMS performed for non-melanoma skin cancers (NMSC) of the head at the Skin and Cancer Foundation Australia, Westmead, between 1 January and 31 December 2007.

RESULTS

Tumor size was the main factor involved in the final defect size (r : 0.60, P < 0.001), but the sex and age of the patient, tumour pathology, site and surgeon were also significantly associated with the final defect size. In a multivariate analysis, only sex did not remain as an independent factor. Regarding closure method, the age of the patient, defect size, site and surgeon were significantly associated, but patient's age did not remain significant in the multivariate analysis.

CONCLUSION

Our study has demonstrated that the performing surgeon is a relevant factor in the determination of defect size and repair methods in MMS. The factors underlying this variability require further study as decisions on closure method should be made objectively, based on patient-related and tumour-related factors. As expected, the location and size of the defect are the other factors that determine the chosen method of repair.

摘要

背景/目的:在莫氏显微外科手术(MMS)中,皮肤科医生同时担任外科医生、病理学家和重建外科医生。分析在确定缺损大小和闭合类型中起作用的因素可能会带来更好的患者预后。目的是确定导致MMS中缺损大小和所采用闭合方法的因素。

方法

对2007年1月1日至12月31日期间在澳大利亚韦斯特米德皮肤与癌症基金会为头部非黑色素瘤皮肤癌(NMSC)进行的所有MMS手术进行回顾性分析。

结果

肿瘤大小是影响最终缺损大小的主要因素(r = 0.60,P < 0.001),但患者的性别和年龄、肿瘤病理、部位和外科医生也与最终缺损大小显著相关。在多变量分析中,只有性别不再是独立因素。关于闭合方法,患者年龄、缺损大小、部位和外科医生显著相关,但在多变量分析中患者年龄不再显著。

结论

我们的研究表明,实施手术的外科医生是MMS中确定缺损大小和修复方法的一个相关因素。这种变异性背后的因素需要进一步研究,因为闭合方法的决策应基于患者相关和肿瘤相关因素客观做出。正如预期的那样,缺损的位置和大小是决定所选修复方法的其他因素。

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