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妇科手术中的单剂量预防:阿莫西林/克拉维酸与头孢呋辛和甲硝唑联合用药的随机前瞻性比较

Single-dose prophylaxis in gynaecological surgery: amoxycillin/clavulanic acid versus the combination of cefuroxim and metronidazole in a randomized prospective comparison.

作者信息

Friese S, Pricker G J, Willems F T, Loriaux S M

机构信息

Department of Obstetrics and Gynaecology, Stichting Ignatius Ziekenhuis Breda, The Netherlands.

出版信息

Eur J Obstet Gynecol Reprod Biol. 1988 Apr;27(4):313-7. doi: 10.1016/0028-2243(88)90044-5.

DOI:10.1016/0028-2243(88)90044-5
PMID:3384164
Abstract

A prospective randomized study was conducted comparing a single 2.2 g preoperative dose amoxycillin/clavulanic acid with a regimen of 1.5 g cefuroxim combined with 0.5 g metronidazole. Two hundred and fifty-one women were evaluated in this comparative study. The febrile morbidity, the incidence of urinary tract infections and the hospital stay were similar in both regimens. A single preoperative dose of amoxycillin/clavulanic acid was as effective as a combined regimen of cefuroxim and metronidazole and less expensive.

摘要

进行了一项前瞻性随机研究,比较术前单次给予2.2克阿莫西林/克拉维酸与1.5克头孢呋辛联合0.5克甲硝唑的治疗方案。在这项比较研究中评估了251名女性。两种治疗方案的发热发病率、尿路感染发生率和住院时间相似。术前单次剂量的阿莫西林/克拉维酸与头孢呋辛和甲硝唑联合治疗方案效果相同且成本更低。

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Single-dose prophylaxis in gynaecological surgery: amoxycillin/clavulanic acid versus the combination of cefuroxim and metronidazole in a randomized prospective comparison.妇科手术中的单剂量预防:阿莫西林/克拉维酸与头孢呋辛和甲硝唑联合用药的随机前瞻性比较
Eur J Obstet Gynecol Reprod Biol. 1988 Apr;27(4):313-7. doi: 10.1016/0028-2243(88)90044-5.
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Prophylaxis in gynaecological surgery: a prospective randomized comparison between single dose prophylaxis with amoxycillin/clavulanate and the combination of cefuroxime and metronidazole.妇科手术中的预防措施:阿莫西林/克拉维酸单剂量预防与头孢呋辛和甲硝唑联合使用的前瞻性随机比较。
J Antimicrob Chemother. 1989 Nov;24 Suppl B:213-6. doi: 10.1093/jac/24.suppl_b.213.
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A prospective randomized study comparing amoxycillin/clavulanate with cefuroxime plus metronidazole for perioperative prophylaxis in gynaecological surgery.一项比较阿莫西林/克拉维酸盐与头孢呋辛加甲硝唑用于妇科手术围手术期预防的前瞻性随机研究。
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Urinary tract infections after pelvic floor gynecological surgery: prevalence and effect of antimicrobial prophylaxis. A systematic review.盆底妇科手术后的尿路感染:抗菌药物预防的患病率及效果。一项系统评价。
Int Urogynecol J Pelvic Floor Dysfunct. 2008 Aug;19(8):1165-72. doi: 10.1007/s00192-008-0584-0. Epub 2008 Apr 10.