作为潜在治疗剂的咪唑衍生物
Imidazole Derivatives as Potential Therapeutic Agents.
作者信息
Sharma Archana, Kumar Vipin, Kharb Rajeev, Kumar Sunil, Sharma Prabodh Chander, Pathak Dharam Pal
机构信息
Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra-136119, India.
出版信息
Curr Pharm Des. 2016;22(21):3265-301. doi: 10.2174/1381612822666160226144333.
BACKGROUND
The imidazole nucleus is inimitable and ubiquitous and it is very well known to play an important role in living organisms. Imidazole derivatives are under intensive scientific exploration due to their diverse and significant pharmacological activities.
METHODS
The present paper is an attempt to discuss chemistry, synthetic aspects including click chemistry procedures of imidazoles through systematic literature survey.
RESULTS
Biological activity profiles of the imidazole derivatives reported in recent scientific literature from 2000 to 2015 have been discussed in detail. It has been found that imidazole derivatives depict appreciable antiinfective activity potential.
CONCLUSION
It is anticipated that the information compiled in this paper will be useful and motivating to prospective researchers working on this heterocylic scaffold.
背景
咪唑核独一无二且普遍存在，在生物体内发挥重要作用广为人知。咪唑衍生物因其多样且显著的药理活性而受到深入的科学探索。
方法
本文试图通过系统的文献调研来讨论咪唑的化学、合成方面，包括点击化学程序。
结果
详细讨论了2000年至2015年近期科学文献中报道的咪唑衍生物的生物活性概况。已发现咪唑衍生物具有可观的抗感染活性潜力。
结论
预计本文汇编的信息将对从事这种杂环骨架研究的未来研究人员有用且具有启发性。
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