铁催化咪唑杂环与氨基甲酸酯的区域选择性烷氧基羰基化反应

Iron-Catalyzed Regioselective Alkoxycarbonylation of Imidazoheterocycles with Carbazates.

作者信息

Gao Yongyuan, Lu Weiye, Liu Ping, Sun Peipei

机构信息

College of Chemistry and Materials Science, Jiangsu Provincial Key Laboratory of Material Cycle Processes and Pollution Control, Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Nanjing Normal University , Nanjing 210023, China.

出版信息

J Org Chem. 2016 Mar 18;81(6):2482-7. doi: 10.1021/acs.joc.6b00046. Epub 2016 Mar 7.

DOI:10.1021/acs.joc.6b00046

PMID:26916233

Abstract

A regioselective alkoxycarbonylation of imidazoheterocycles using carbazates as ester group sources in DMSO was developed, in which an inexpensive FeCl2·4H2O was used as the catalyst and (NH4)2S2O8 was the oxidant. The reaction proceeded smoothly under an air atmosphere to give the 3-alkoxycarbonylated products in moderate to good yields.

摘要

开发了一种在二甲基亚砜中使用氨基甲酸酯作为酯基源对咪唑杂环进行区域选择性烷氧羰基化反应，其中使用廉价的四水合氯化亚铁作为催化剂，过硫酸铵为氧化剂。该反应在空气气氛下顺利进行，以中等到良好的产率得到3-烷氧羰基化产物。