铁催化 N-芳基丙烯酰胺与卡巴酯的芳基烷氧基羰基化反应。
Iron-catalyzed arylalkoxycarbonylation of N-aryl acrylamides with carbazates.
机构信息
College of Chemical Engineering and Materials Science, Zhejiang University of Technology , Hangzhou 310014, P. R. China.
出版信息
J Org Chem. 2014 Jan 3;79(1):446-51. doi: 10.1021/jo402529r. Epub 2013 Dec 20.
PMID:24328134
Abstract
A novel arylalkoxycarbonylation of N-aryl acrylamides with carbazates leading to alkoxycarbonylated oxindoles has been developed. The reported reactions employ economical and environmentally benign FeCl2·4H2O as a catalyst and easily accessible and safe carbazates as alkoxycarbonyl radical precursors.
摘要
发展了一种新型的 N-芳基丙烯酰胺与卡巴酯的芳基烷氧基羰基化反应，生成烷氧基羰基化的吲哚啉酮。所报道的反应采用经济环保的二水合氯化亚铁（FeCl2·4H2O）作为催化剂，使用易得且安全的卡巴酯作为烷氧基羰基自由基前体。
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