Stansborough Romany L, Al-Dasooqi Noor, Bateman Emma H, Keefe Dorothy M K, Gibson Rachel J
a School of Medicine , University of Adelaide , Adelaide , Australia.
Int J Radiat Biol. 2016 May;92(5):241-8. doi: 10.3109/09553002.2016.1146830. Epub 2016 Feb 26.
Purpose To review the literature surrounding the involvement of the endothelium and matrix metalloproteinases (MMP) in radiotherapy-induced gut toxicity (RIGT) and further elucidate its complex pathobiology. Results RIGT involves damage to the gastrointestinal mucosa and is associated with diarrhoea, pain, and rectal bleeding depending on the area of exposure. The mechanisms underpinning RIGT are complex and have not yet been elucidated. Members of the MMP family, particularly MMP-2 and -9, have recently been identified as being key markers in RIGT and chemotherapy-induced gut toxicity (CIGT). Furthermore, the microvasculature has long been implicated in the development of toxicities following both chemotherapy and radiotherapy, however, the mechanisms behind this are yet to be explored. Conclusions It is proposed that matrix metalloproteinases are key regulators of endothelial mediators, and may play a key role in inducing damage to intestinal microvasculature following radiotherapy.
回顾有关内皮细胞和基质金属蛋白酶（MMP）参与放疗诱导的肠道毒性（RIGT）的文献，并进一步阐明其复杂的病理生物学机制。结果：RIGT涉及胃肠道黏膜损伤，并根据暴露区域的不同，伴有腹泻、疼痛和直肠出血。RIGT的潜在机制很复杂，尚未完全阐明。MMP家族成员，特别是MMP-2和-9，最近被确定为RIGT和化疗诱导的肠道毒性（CIGT）的关键标志物。此外，长期以来，微血管系统一直被认为与化疗和放疗后的毒性发展有关，然而，其背后的机制尚待探索。结论：有人提出，基质金属蛋白酶是内皮介质的关键调节因子，可能在放疗后诱导肠道微血管损伤中起关键作用。
