在高剪切速率下研究溶液：一种专用的微流控装置。
Studying solutions at high shear rates: a dedicated microfluidics setup.
作者信息
Wieland D C F, Garamus V M, Zander T, Krywka C, Wang M, Dedinaite A, Claesson P M, Willumeit-Römer R
机构信息
Institute for Materials Research, Helmholtz-Zentrum Geestacht: Centre for Materials and Coast Research, Max-Planck-Strasse 1, Geesthacht 21502, Germany.
Department of Chemistry, Surface and Corrosion Science, KTH Royal Institute of Technology, Drottning Kristinas väg 51, Stockholm 10044, Sweden.
出版信息
J Synchrotron Radiat. 2016 Mar;23(2):480-6. doi: 10.1107/S1600577515024856. Epub 2016 Feb 12.
The development of a dedicated small-angle X-ray scattering setup for the investigation of complex fluids at different controlled shear conditions is reported. The setup utilizes a microfluidics chip with a narrowing channel. As a consequence, a shear gradient is generated within the channel and the effect of shear rate on structure and interactions is mapped spatially. In a first experiment small-angle X-ray scattering is utilized to investigate highly concentrated protein solutions up to a shear rate of 300000 s(-1). These data demonstrate that equilibrium clusters of lysozyme are destabilized at high shear rates.
报道了一种专门用于在不同可控剪切条件下研究复杂流体的小角X射线散射装置的开发。该装置利用了一个带有变窄通道的微流控芯片。因此，在通道内产生了剪切梯度，并且剪切速率对结构和相互作用的影响在空间上得到了映射。在第一个实验中，利用小角X射线散射研究了高达300000 s(-1)剪切速率的高浓度蛋白质溶液。这些数据表明，溶菌酶的平衡聚集体在高剪切速率下会变得不稳定。
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