Pelliccia Daniele, Poole Christopher M, Livingstone Jayde, Stevenson Andrew W, Smyth Lloyd M L, Rogers Peter A W, Haüsermann Daniel, Crosbie Jeffrey C
School of Science, RMIT University, Melbourne, Victoria 3001, Australia.
Australian Synchrotron, Clayton, Victoria 3168, Australia.
J Synchrotron Radiat. 2016 Mar;23(2):566-73. doi: 10.1107/S1600577515022894. Epub 2016 Jan 28.
The protocol for image-guided microbeam radiotherapy (MRT) developed for the Australian Synchrotron's Imaging and Medical Beamline (IMBL) is described. The protocol has been designed for the small-animal MRT station of IMBL to enable future preclinical trials on rodents. The image guidance procedure allows for low-dose monochromatic imaging at 50 keV and subsequent semi-automated sample alignment in 3D with sub-100 µm accuracy. Following the alignment, a beamline operation mode change is performed and the relevant beamline components are automatically aligned for the treatment (pink) beam to be delivered on the sample. Here, the small-animal MRT station, the parameters and procedures for the image guidance protocol, as well as the experimental imaging results using phantoms are described. Furthermore, the experimental validation of the protocol using 3D PRESAGE(®) dosimeters is reported. It is demonstrated that the sample alignment is maintained after the mode change and the treatment can be delivered within the same spatial accuracy of 100 µm. The results indicate that the proposed approach is viable for preclinical trials of small-animal MRT.
本文描述了为澳大利亚同步加速器的成像与医学光束线（IMBL）开发的图像引导微束放射治疗（MRT）方案。该方案是为IMBL的小动物MRT工作站设计的，以便未来在啮齿动物身上进行临床前试验。图像引导程序允许在50 keV下进行低剂量单色成像，并随后以低于100 µm的精度在三维空间中进行半自动样品对准。对准后，进行光束线操作模式切换，并自动对准相关光束线组件，以便将治疗（粉红）光束照射到样品上。这里描述了小动物MRT工作站、图像引导方案的参数和程序，以及使用体模的实验成像结果。此外，还报告了使用3D PRESAGE(®)剂量计对该方案进行的实验验证。结果表明，模式切换后样品对准得以保持，并且可以在100 µm的相同空间精度内进行治疗。结果表明，所提出的方法对于小动物MRT的临床前试验是可行的。
