Villanueva C, Monés J, Pujol R, Puig L, Such J, Sancho F J
Med Clin (Barc). 1989 Sep 23;93(8):298-300.
The concept of acute febrile neutrophilic dermatosis (Sweet's syndrome) has evolved and expanded to include, under the denomination of neutrophilic dermatosis (ND), both pyoderma gangrenosum and the intestinal bypass syndrome, with or without intestinal bypass, vesicular and pustular rash associated with ulcerative colitis (UC), and Sweet's syndrome itself. Among the skin lesions associated with UC several types of vesicular and pustular rash have been reported and, very rarely, the association of UC and Sweet's syndrome has been reported. We report a female with UC who developed a vesicular and pustular rash associated with an exacerbation of her colonic disease. Two years later she developed a characteristic Sweet's syndrome coincident with another exacerbation of UC. The concurrence of two different forms of ND associated with successive exacerbations of UC supports the concept of ND as an individual condition with several types of clinical presentation.
急性发热性嗜中性皮病（Sweet综合征）的概念已经演变并扩展，在嗜中性皮病（ND）这一名称下，包括坏疽性脓皮病和肠道旁路综合征（无论有无肠道旁路）、与溃疡性结肠炎（UC）相关的水疱脓疱性皮疹以及Sweet综合征本身。在与UC相关的皮肤病变中，已经报道了几种类型的水疱脓疱性皮疹，并且极少见UC与Sweet综合征相关的报道。我们报告一名患有UC的女性，在结肠疾病加重时出现了水疱脓疱性皮疹。两年后，她在UC再次加重时出现了典型的Sweet综合征。两种不同形式的ND与UC的连续加重同时出现，支持了ND是一种具有多种临床表现类型的独立疾病的概念。
