Keshavarzian A, Bushnell D L, Sontag S, Yegelwel E J, Smid K
Department of Medicine and Pharmacology, Loyola University School of Medicine, Maywood, Illinois.
Am J Gastroenterol. 1991 Jun;86(6):738-42.
The pathogenesis of gastroesophageal reflux (GER) is not fully understood. There have been reports that delayed gastric emptying is a contributing factor in some patients. To determine whether delayed gastric emptying plays a role in the genesis of GER, we correlated gastric-emptying measures obtained by scintigraphic techniques with the degree of acid reflux assessed by esophageal pH monitoring. Ten patients, all of whom had evidence of esophageal mucosal disease and severe acid reflux, were studied. Four of the 10 patients with reflux had prolongation in the lag phase of gastric solid emptying, and one of the four showed prolonged gastric-emptying t1/2. There was no significant difference, however, in the mean gastric-emptying t1/2 between a control group and the patient group. Furthermore, there was no correlation between gastric-emptying measures and degree of acid reflux. We conclude that in this group of 10 patients with severe GER, delayed gastric emptying does not play an important role in the development of gastroesophageal reflux.
胃食管反流（GER）的发病机制尚未完全明确。有报道称，胃排空延迟在部分患者中是一个促成因素。为了确定胃排空延迟是否在GER的发生中起作用，我们将通过闪烁扫描技术获得的胃排空指标与通过食管pH监测评估的酸反流程度进行了关联分析。对10例均有食管黏膜病变及严重酸反流证据的患者进行了研究。10例反流患者中有4例胃固体排空的延迟期延长，其中1例胃排空t1/2延长。然而，对照组与患者组之间的平均胃排空t1/2并无显著差异。此外，胃排空指标与酸反流程度之间也没有相关性。我们得出结论，在这组10例严重GER患者中，胃排空延迟在胃食管反流的发展过程中并不起重要作用。
