Shibata H, Harasawa S, Miwa T
Tokai J Exp Clin Med. 1985 Dec;10(6):631-6.
Forty-two patients with reflux esophagitis were referred for gastric emptying evaluations. Esophageal manometry was performed on them. Gastric emptying was significantly delayed in patients with reflux esophagitis compared to normal subjects. Lower esophageal sphincter pressure (LESP) showed no significant difference between patients and controls. Acid clearing test was prolonged in patients with reflux esophagitis more than in normal subjects. The subjects were divided into two groups for gastric emptying evaluations; a group with delayed gastric emptying and one with rapid gastric emptying as compared with normal criteria. LESP in 7 cases of rapid gastric emptying among 42 patients (16.6%) was only significantly lower than in normal subjects. The pathogenesis of reflux esophagitis had been previously thought to be a low LESP and/or a prolonged acid clearing. However, we think that a delayed gastric emptying may be one of the pathogenetic characteristics.
42例反流性食管炎患者被转诊进行胃排空评估。对他们进行了食管测压。与正常受试者相比，反流性食管炎患者的胃排空明显延迟。患者与对照组之间的食管下括约肌压力（LESP）无显著差异。反流性食管炎患者的酸清除试验比正常受试者延长。为进行胃排空评估，将受试者分为两组；一组胃排空延迟，另一组与正常标准相比胃排空迅速。42例患者中有7例胃排空迅速（16.6%），其LESP仅显著低于正常受试者。反流性食管炎的发病机制以前被认为是LESP降低和/或酸清除延长。然而，我们认为胃排空延迟可能是发病特征之一。
