布拉德福德大鼠脑结构中的磷脂和糖脂合成。

Phospholipid and glycolipid synthesis in brain structures of Brattleboro rats.

作者信息

Dishkelov A, Mitev Y, Patchev V

机构信息

Brain Research Institute, Bulgarian Academy of Sciences, Sofia.

出版信息

Life Sci. 1989;45(25):2401-4. doi: 10.1016/0024-3205(89)90003-9.

DOI:10.1016/0024-3205(89)90003-9

PMID:2691792

Abstract

The incorporation of labeled precursors in phospholipids and glycolipids was studied in discrete brain areas of rats with innate vasopressin deficiency (Brattleboro, DI) and intact Long Evans animals (LE). Tracer incorporation was found to be reduced in septal, hypothalamic and hippocampal phospholipids, but enhanced in the glycolipid fraction isolated from the hypothalamus and hippocampus of Brattleboro rats. The results indicate that inherited vasopressin deficit seems to be associated with altered lipid synthesis in some brain areas of the Brattleboro rat, suggesting a probability for impaired translation of chemical signals.

摘要

在先天性血管加压素缺乏的大鼠（布拉德福德，尿崩症，DI）和正常的朗伊 Evans 动物（LE）的离散脑区中，研究了标记前体在磷脂和糖脂中的掺入情况。发现中隔、下丘脑和海马磷脂中的示踪剂掺入减少，但从布拉德福德大鼠的下丘脑和海马分离出的糖脂部分中示踪剂掺入增加。结果表明，遗传性血管加压素缺乏似乎与布拉德福德大鼠某些脑区的脂质合成改变有关，提示化学信号转导受损的可能性。