Brodie J
J Hyg (Lond). 1977 Oct;79(2):181-92. doi: 10.1017/s0022172400052980.
In a previous paper (Brodie, 1977) the value of the Widal test in the diagnosis of typhoid fever was shown to be limited. Evaluation of possible alternative tests showed that: (1) the sensitivity of the anti-human globulin (Coombs') test appeared greater than that of the agglutination test but the length of time (48 h) before results were available rendered it of little value in rapid diagnosis: (2) the complement fixation test offered no particular help towards diagnosis; (3) immunized and non-immunized typhoid fever patients developed fimbrial antibodies, as also did immunized healthy individuals. In this latter group, however, those immunized with alcoholized TAB vaccine had higher antibody titres to fimbrial antigen than those immunized with heat-killed phenolized vaccine.
在之前的一篇论文（布罗迪，1977年）中，维达试验在伤寒热诊断中的价值已被证明是有限的。对可能的替代试验的评估表明：（1）抗人球蛋白（库姆斯氏）试验的敏感性似乎高于凝集试验，但在获得结果之前所需的时间（48小时）使得它在快速诊断中几乎没有价值；（2）补体结合试验对诊断没有特别的帮助；（3）免疫和未免疫的伤寒热患者都产生了菌毛抗体，免疫的健康个体也是如此。然而，在后一组中，用乙醇处理的伤寒、副伤寒甲、乙三联菌苗（TAB）疫苗免疫的个体对菌毛抗原的抗体滴度高于用热灭活酚化疫苗免疫的个体。
