Pourbehi Mohammad Reza, Zahedi Talieh, Darabi Hossein, Ostovar Afshin, Assadi Majid, Nabipour Iraj
Endocr Pract. 2016 Jul;22(7):780-5. doi: 10.4158/EP151134.OR. Epub 2016 Feb 26.
There is growing evidence that supports the existence of a link between lower levels of circulating omentin-1 and the pathogenesis of coronary atherosclerosis. However, no population-based study has been performed to elucidate the cardioprotective role of this beneficial adipocytokine.
A total of 378 healthy, postmenopausal women were randomly selected from 13 clusters in the port city of Bushehr, Iran. The prevalence of nonfatal ischemic heart disease (IHD) was assessed using the Minnesota code with a 12-lead resting electrocardiogram (EKG). EKG with evidence of IHD (IHD-EKG) was defined as myocardial infarction (codes 1.1 and 1.2) and ischemia (codes 1.3, 4.1 to 4.4, 5.1 to 5.3, and 7.1) occurring together. Serum omentin-1 and adiponectin levels were measured using enzyme-linked immunosorbent assay methods.
The prevalence of IHD-EKG among the studied population was 41.8% (159 women). Serum levels of omentin-1 were significantly lower in women with ischemic EKG than in normal subjects (geometric mean ×/multiplicative standard deviation, 10.31 ×/2.35 ng/mL versus 12.44 ×/2.12 ng/mL, respectively; P = .038). Multiple logistic regression analysis indicated that higher serum levels of omentin-1 were significantly associated with a lower prevalence of ischemic EKG after adjusting for potential confounders, including classical cardiovascular risk factors and circulating adiponectin levels (odds ratio, 0.48; confidence interval, 0.24 to 0.95; P = .038).
A higher level of circulating omentin-1 is independently associated with a lower prevalence of nonfatal IHD in postmenopausal women. The cardioprotective role of this novel adipocytokine needs to be further elucidated in large-scale longitudinal studies.
BMI = body mass index EKG = electrocardiogram ELISA = enzyme-linked immunosorbent assay HDL = high-density lipoprotein IHD = ischemic heart disease LDL = low-density lipoprotein.
越来越多的证据支持循环中网膜素-1水平降低与冠状动脉粥样硬化发病机制之间存在联系。然而，尚未有基于人群的研究来阐明这种有益脂肪细胞因子的心脏保护作用。
从伊朗布什尔港城市的13个群组中随机选取了378名健康的绝经后女性。使用明尼苏达编码和12导联静息心电图（EKG）评估非致命性缺血性心脏病（IHD）的患病率。有IHD证据的EKG（IHD-EKG）定义为心肌梗死（编码1.1和1.2）和缺血（编码1.3、4.1至4.4、5.1至5.3和7.1）同时出现。采用酶联免疫吸附测定法测量血清网膜素-1和脂联素水平。
研究人群中IHD-EKG的患病率为41.8%（159名女性）。缺血性EKG女性的血清网膜素-1水平显著低于正常受试者（几何均值×/乘性标准差，分别为10.31×/2.35 ng/mL和12.44×/2.12 ng/mL；P = 0.038）。多因素逻辑回归分析表明，在调整潜在混杂因素（包括经典心血管危险因素和循环脂联素水平）后，血清网膜素-1水平较高与缺血性EKG患病率较低显著相关（比值比，0.48；置信区间，0.24至0.95；P = 0.038）。
循环中较高水平的网膜素-1与绝经后女性非致命性IHD的较低患病率独立相关。这种新型脂肪细胞因子的心脏保护作用需要在大规模纵向研究中进一步阐明。
BMI = 体重指数；EKG = 心电图；ELISA = 酶联免疫吸附测定；HDL = 高密度脂蛋白；IHD = 缺血性心脏病；LDL = 低密度脂蛋白
