Han Shiwen, Zou Shiying, He Xiaoyun, Huang Kunlun, Mei Xiaohong
College of Food Science and Nutritional Engineering, China Agricultural University, No. 17 Tsinghua Donglu, Beijing, 100083, China.
The Supervision, Inspection and Testing Center of Genetically Modified Organisms, Ministry of Agriculture, Beijing, 100083, China.
Transgenic Res. 2016 Aug;25(4):453-63. doi: 10.1007/s11248-016-9944-6. Epub 2016 Feb 26.
The food safety of stacked trait genetically modified (GM) maize GH5112E-117C containing insect-resistance gene Cry1Ah and glyphosate-resistant gene G2-aroA was evaluated in comparison to non-GM Hi-II maize fed to Sprague-Dawley rats during a 90-day subchronic feeding study. Three different dietary concentrations (12.5, 25 and 50 %, w/w) of the GM maize were used or its corresponding non-GM maize. No biologically significant differences in the animals' clinical signs, body weights, food consumption, hematology, clinical chemistry, organ weights and histopathology were found between the stacked trait GM maize groups, and the non-GM maize groups. The results of the 90-day subchronic feeding study demonstrated that the stacked trait GM maize GH5112E-117C is as safe as the conventional non-GM maize Hi-II.
在一项为期90天的亚慢性喂养研究中，将含有抗虫基因Cry1Ah和抗草甘膦基因G2-aroA的叠加性状转基因玉米GH5112E-117C与喂食给斯普拉格-道利大鼠的非转基因Hi-II玉米进行比较，评估了其食品安全。使用了三种不同饮食浓度（12.5%、25%和50%，w/w）的转基因玉米或其相应的非转基因玉米。在叠加性状转基因玉米组和非转基因玉米组之间，未发现动物的临床体征、体重、食物消耗、血液学、临床化学、器官重量和组织病理学有生物学上的显著差异。90天亚慢性喂养研究的结果表明，叠加性状转基因玉米GH5112E-117C与传统非转基因玉米Hi-II一样安全。
