老年人使用左旋多巴相关的视幻觉。
Visual hallucinations in the elderly associated with the use of levodopa.
作者信息
Banerjee A K, Falkai P G, Savidge M
机构信息
Division of Cell Biology, M.R.C. Clinical Research Centre, Northwick Park Hospital, Harrow, Middlesex, UK.
出版信息
Postgrad Med J. 1989 Jun;65(764):358-61. doi: 10.1136/pgmj.65.764.358.
Abstract
Visual hallucinations are a well recognized unwanted effect of treatment with levodopa. Although many individual cases have been reported, there has only been one review previously published about this finding, and this did not discriminate age groups. We present five cases and briefly review the literature. It is important to enquire specifically about visual hallucinations in patients on levodopa therapy at follow up, as this otherwise potentially reversible side effect may be overlooked.
摘要
视幻觉是左旋多巴治疗中一种公认的不良效应。尽管已有许多个案报道，但此前仅有一篇关于该发现的综述发表，且该综述未区分年龄组。我们呈现5例病例并简要回顾文献。在随访时，特别询问接受左旋多巴治疗的患者是否出现视幻觉很重要，因为这种原本可能可逆的副作用可能会被忽视。
相似文献
1
Visual hallucinations in the elderly associated with the use of levodopa.老年人使用左旋多巴相关的视幻觉。
Postgrad Med J. 1989 Jun;65(764):358-61. doi: 10.1136/pgmj.65.764.358.
2
L-tryptophan administration in L-dopa-induced hallucinations in elderly Parkinsonian patients.
Gerontology. 1977;23(6):438-44. doi: 10.1159/000212220.
3
Cenesthetic hallucinations in a patient with Parkinson's disease.一名帕金森病患者的本体感觉幻觉
J Neurol Neurosurg Psychiatry. 1997 Jul;63(1):120. doi: 10.1136/jnnp.63.1.120.
4
Risperidone for hallucinations in levodopa-treated Parkinson's disease patients.
Lancet. 1994 May 28;343(8909):1370-1. doi: 10.1016/s0140-6736(94)92511-9.
5
Behavioral indicators of hallucinosis in levodopa-treated Parkinson's disease.左旋多巴治疗帕金森病中幻觉症的行为指标。
Adv Neurol. 1987;45:417-20.
6
[Hallucinations in Parkinson's disease].[帕金森病中的幻觉]
Nervenarzt. 2003 Apr;74(4):376-85, quiz 385-6. doi: 10.1007/s00115-003-1511-8.
7
Relationship between age and subtypes of psychotic symptoms in Parkinson's disease.帕金森病中年龄与精神症状亚型之间的关系。
J Neurol. 2007 Apr;254(4):448-52. doi: 10.1007/s00415-006-0388-4. Epub 2007 Mar 31.
8
The prevalence and aetiology of long-term L-dopa side-effects in elderly parkinsonian patients.老年帕金森病患者长期左旋多巴副作用的患病率及病因
Age Ageing. 1989 Jan;18(1):11-6. doi: 10.1093/ageing/18.1.11.
9
Clozapine for psychosis in Parkinson's disease.
Mov Disord. 1990;5(3):239-42. doi: 10.1002/mds.870050310.
10
Levodopa-induced psychosis: a kindling phenomenon.
Am J Psychiatry. 1978 Jun;135(6):669-75. doi: 10.1176/ajp.135.6.669.
引用本文的文献
1
The relationship between paracingulate sulcus length and visual hallucinations in Parkinson's disease suggests a neurobiological predisposition.帕金森病中扣带旁沟长度与视幻觉之间的关系提示了一种神经生物学易感性。
Sci Rep. 2025 Jul 2;15(1):23123. doi: 10.1038/s41598-025-04513-3.
2
Prevalence of hallucinations in Parkinson's patients: meta-analysis of International studies.帕金森病患者幻觉的患病率：国际研究的荟萃分析
Neurol Sci. 2023 Oct;44(10):3389-3394. doi: 10.1007/s10072-023-06831-8. Epub 2023 May 4.
3
Motor Complications and Treatment in Advanced Parkinson's Disease #456.晚期帕金森病的运动并发症及治疗#456
J Palliat Med. 2023 May;26(5):730-731. doi: 10.1089/jpm.2023.0046.
4
T-type calcium channels as therapeutic targets in essential tremor and Parkinson's disease.T 型钙通道作为特发性震颤和帕金森病的治疗靶点。
Ann Clin Transl Neurol. 2023 Apr;10(4):462-483. doi: 10.1002/acn3.51735. Epub 2023 Feb 4.
5
Approach to Cognitive Impairment in Parkinson's Disease.帕金森病认知障碍的处理方法。
Neurotherapeutics. 2020 Oct;17(4):1495-1510. doi: 10.1007/s13311-020-00963-x. Epub 2020 Nov 17.
6
L-Dopa and Brain Serotonin System Dysfunction.左旋多巴与脑血清素系统功能障碍。
Toxics. 2015 Mar 5;3(1):75-88. doi: 10.3390/toxics3010075.
7
Behavioral impairments and serotonin reductions in rats after chronic L-dopa.长期使用左旋多巴后大鼠的行为障碍和血清素减少。
Psychopharmacology (Berl). 2015 Sep;232(17):3203-13. doi: 10.1007/s00213-015-3980-4. Epub 2015 Jun 3.
8
Cerebral correlates of psychotic syndromes in neurodegenerative diseases.神经退行性疾病中精神病综合征的大脑相关性。
J Cell Mol Med. 2012 May;16(5):995-1012. doi: 10.1111/j.1582-4934.2011.01311.x.
9
Salsolinol, catecholamine metabolites, and visual hallucinations in L-dopa treated patients with Parkinson's disease.左旋多巴治疗的帕金森病患者中的salsolinol、儿茶酚胺代谢产物与视幻觉
J Neural Transm (Vienna). 1996;103(4):421-32. doi: 10.1007/BF01276418.
本文引用的文献
1
Complications of chronic levodopa therapy: long-term efficacy of drug holiday.慢性左旋多巴治疗的并发症：药物假期的长期疗效
Neurology. 1981 Apr;31(4):473-6. doi: 10.1212/wnl.31.4.473.
2
Drug holiday and management of Parkinson disease.药物假期与帕金森病的管理
Neurology. 1980 Dec;30(12):1257-61. doi: 10.1212/wnl.30.12.1257.
3
Psychiatric complications of levodopa therapy of Parkinson's disease.帕金森病左旋多巴治疗的精神科并发症
Adv Neurol. 1984;40:271-7.
4
Mental disorders in Parkinson's disease after treatment with L-DOPA.
Adv Neurol. 1984;40:259-69.
5
Psychiatric aspects in Parkinsonism treated with L-dopa.左旋多巴治疗帕金森病的精神方面问题。
J Neurol Neurosurg Psychiatry. 1971 Oct;34(5):502-7. doi: 10.1136/jnnp.34.5.502.
6
Attempted use of haloperidol in the treatment of L-dopa induced dyskinesias.尝试使用氟哌啶醇治疗左旋多巴诱发的运动障碍。
J Neurol Neurosurg Psychiatry. 1974 Apr;37(4):427-30. doi: 10.1136/jnnp.37.4.427.
7
Mental symptoms in Parkinsonian patients treated with L-dopa.
Lancet. 1970 Jul 25;2(7665):177-9. doi: 10.1016/s0140-6736(70)92535-3.
8
Effects of L-dopa in patients with dementia.
Lancet. 1970 Jun 6;1(7658):1231. doi: 10.1016/s0140-6736(70)91820-9.
9
Inappropriate prescribing in the elderly.老年人不适当用药
J R Coll Physicians Lond. 1987 Jan;21(1):39-41.
10
Mental symptoms in Parkinson's disease during chronic treatment with levodopa.
Neurology. 1976 Apr;26(4):305-10. doi: 10.1212/wnl.26.4.305.
Zotero 插件