Moser A, Siebecker F, Vieregge P, Jaskowski P, Kömpf D
Department of Neurology, Medical University, Lübeck, Federal Republic of Germany.
J Neural Transm (Vienna). 1996;103(4):421-32. doi: 10.1007/BF01276418.
We could quantify the tetrahydroisoquinoline derivative salsolinol in urine of patients with Parkinson's disease and normal control subjects by means of high performance liquid chromatography and electrochemical detection. Urine levels of salsolinol were positively related to the homovanillic acid/3-O-methyl-dopa ratio in the cerebrospinal fluid that reflects dopamine metabolism. In the patient group with visual hallucinations, mean salsolinol level was significantly increased to almost the 3-fold of those found in patients without hallucinations. Since the daily L-dopa doses of both patient groups were nearly identical this result is not due to different L-dopa medications. Additionally, either high values of the main serotonin metabolite, 5-hydroxyindole acetic acid (HIAA) or the L-dopa/3-O-methyl-dopa ratio were found in cerebrospinal fluid of patients with hallucinations. The enhanced salsolinol levels in patients with visual hallucinations seem to be due to an overloaded dopaminergic pathway with an imbalance between dopaminergic and serotonergic systems. Thus, salsolinol appears as a predictor for hallucinosis in Parkinson's disease.
我们可以通过高效液相色谱法和电化学检测法对帕金森病患者及正常对照者尿液中的四氢异喹啉衍生物萨索林醇进行定量分析。萨索林醇的尿液水平与反映多巴胺代谢的脑脊液中高香草酸/3 - O - 甲基多巴比值呈正相关。在有视幻觉的患者组中，萨索林醇的平均水平显著升高，几乎是无幻觉患者的3倍。由于两组患者的每日左旋多巴剂量几乎相同，所以这一结果并非由不同的左旋多巴用药所致。此外，在有幻觉的患者脑脊液中，主要血清素代谢产物5 - 羟吲哚乙酸（5 - HIAA）的值或左旋多巴/3 - O - 甲基多巴比值较高。视幻觉患者萨索林醇水平升高似乎是由于多巴胺能通路过载，多巴胺能和血清素能系统之间失衡所致。因此，萨索林醇似乎是帕金森病幻觉症的一个预测指标。
