Division of Infectious Diseases, Department of Internal Medicine, Tungs' Taichung MetroHarbor Hospital, Taichung, Taiwan, ROC.
Institutes of Clinical Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, ROC.
J Infect. 2016 May;72(5):608-14. doi: 10.1016/j.jinf.2016.01.016. Epub 2016 Feb 24.
To disclose the association between diabetes mellitus (DM) and cryptococcosis in HIV-uninfected patients.
Case patients' diagnoses with cryptococcosis and cryptococcal meningitis were based on data from the Taiwan National Health Insurance Research Database from 2000 to 2010, and diagnoses were defined using the International Classification of Disease, Ninth Revision, Clinical Modification. A case-control study comprising inpatient and outpatient populations was conducted using 4 controls for each patient (4587 case patients and 18,348 controls) matched for age, sex, monthly income, and urbanization level.
Human immunodeficiency virus (HIV)-uninfected patients with cryptococcosis were more likely to have diabetes than matched control patients (adjusted odds ratio [OR], 1.45; 95% confidence interval [95% CI], 1.36-1.64; p < 0.001). A diagnosis of DM was also associated with 1-year and overall mortality from cryptococcosis (hazard ratio [HR], 1.39; 95% CI, 1.17-1.65; p < 0.001, HR, 1.47; 95% CI, 1.29-1.67; p < 0.001; respectively) and cryptococcal meningitis (p = 0.018).
Diabetes was associated with the occurrence of cryptococcosis and cryptococcal meningitis in HIV-uninfected patients. DM was also associated with 1-year and overall mortality for these patients.
揭示 HIV 阴性患者中糖尿病（DM）与隐球菌病之间的关联。
2000 年至 2010 年，基于台湾全民健康保险研究数据库的数据，对隐球菌病和隐球菌性脑膜炎的病例患者进行诊断，采用国际疾病分类，第九修订版，临床修正版进行诊断。采用病例对照研究，包括住院和门诊人群，将每位患者匹配 4 名对照（4587 例病例患者和 18348 名对照），匹配年龄、性别、月收入和城市化水平。
患有隐球菌病的 HIV 阴性患者比匹配的对照患者更有可能患有糖尿病（调整后的优势比[OR]，1.45；95%置信区间[95%CI]，1.36-1.64；p<0.001）。DM 诊断还与隐球菌病的 1 年和总死亡率相关（风险比[HR]，1.39；95%CI，1.17-1.65；p<0.001，HR，1.47；95%CI，1.29-1.67；p<0.001；分别）和隐球菌性脑膜炎（p=0.018）。
糖尿病与 HIV 阴性患者中隐球菌病和隐球菌性脑膜炎的发生相关。DM 还与这些患者的 1 年和总死亡率相关。
