Bloom B S, Daniel J M, Wiseman M, Knorr R S, Cebul R, Kissick W L
University of Pennsylvania, Philadelphia 19104-6020.
Respir Med. 1989 Jul;83(4):281-8. doi: 10.1016/s0954-6111(89)80197-0.
A total of 43 severely ill COPD patients already on 24 h, or near 24 h, per day supplemental O2 were randomly assigned to transtracheal oxygen delivery (n = 22) or usual delivery of O2 by nasal cannula or face mask (n = 21). A few important changes were found in pulmonary function over time such as decreases of PEFR, FEF and MVV for both experimental and control groups, and FEV1% and FEV3% in experimental patients. At the same time, there was a significant decrease in both hematocrit and hemoglobin, and per cent shunting for the experimental group and a significant increase in per cent shunting in the control group. Physical, social and psychologic assessments showed significant improvement over time for experimental patients and declines for the control group. Lastly, medical costs were positively affected, as fewer days were spent in hospital post-study enrollment by experimental than control groups, and post-enrollment relative to pre-enrollment by experimental patients.
共有43名每天已接受24小时或接近24小时补充氧气治疗的重度慢性阻塞性肺疾病（COPD）患者被随机分为经气管输氧组（n = 22）或通过鼻导管或面罩进行常规输氧组（n = 21）。随着时间的推移，两组患者的肺功能均出现了一些重要变化，如实验组和对照组的呼气峰流速（PEFR）、用力呼气流量（FEF）和最大通气量（MVV）均下降，实验组患者的第1秒用力呼气容积百分比（FEV1%）和第3秒用力呼气容积百分比（FEV3%）也下降。同时，实验组的血细胞比容和血红蛋白均显著下降，分流百分比显著下降，而对照组的分流百分比显著增加。身体、社会和心理评估显示，随着时间的推移，实验组患者有显著改善，而对照组则有所下降。最后，医疗费用受到了积极影响，因为实验组患者在研究入组后住院天数少于对照组，且实验组患者入组后相对于入组前的住院天数也减少。
