Walsh D A, Govan J R
Department of Respiratory Medicine, Harefield Hospital, Middlesex.
Thorax. 1990 Jun;45(6):478-81. doi: 10.1136/thx.45.6.478.
Long term continuous oxygen therapy improves prognosis in patients with hypoxaemic chronic airflow limitation. Transtracheal delivery of oxygen permits adequate oxygenation of such patients at lower flow rates than are required for delivery by nasal cannulas, thus increasing the time for which portable oxygen cylinders can be used and improving the efficacy of domiciliary oxygen concentrators in patients with refractory hypoxaemia. In a study of the long term acceptability and risks of transtracheal oxygen in 37 patients, with a total follow up of 595 patient-months, most patients reported symptomatic benefit and four have used transtracheal oxygen successfully for more than four years. Problems have included surgical emphysema (4 patients), catheter fracture (9), local infection (34), and catheter dislodgement (21); but these have been relatively infrequent and in general have not caused important clinical problems. Transtracheal oxygen therapy was discontinued in 10 patients before death for various reasons, including infection (2 patients), catheter fracture (1), and surgical emphysema (1). Accumulation of mucus balls has not been a problem. It is concluded that transtracheal oxygen therapy is a safe and acceptable alternative to nasal cannulas in well motivated patients with hypoxaemia due to chronic airflow limitation who are keen to pursue an active life.
长期持续氧疗可改善低氧性慢性气流受限患者的预后。经气管输氧能使此类患者以低于鼻导管输氧所需的流速实现充分氧合,从而延长便携式氧气瓶的使用时间,并提高难治性低氧血症患者家庭用制氧机的功效。在一项针对37例患者进行的经气管输氧长期可接受性及风险的研究中,总计随访595患者月,大多数患者报告有症状改善,4例患者成功使用经气管输氧超过4年。出现的问题包括手术性气肿(4例患者)、导管断裂(9例)、局部感染(34例)及导管移位(21例);但这些情况相对少见,总体未引发严重临床问题。10例患者在死亡前因各种原因停止经气管输氧治疗,包括感染(2例患者)、导管断裂(1例)及手术性气肿(1例)。黏液球积聚并非问题。结论是,对于因慢性气流受限导致低氧血症且渴望积极生活的有积极性的患者,经气管输氧治疗是鼻导管输氧的一种安全且可接受的替代方法。