对甲型流感病毒复制至关重要的蛋白质-脂质相互作用。
Protein-lipid interactions critical to replication of the influenza A virus.
作者信息
Chlanda Petr, Zimmerberg Joshua
机构信息
Section on Integrative Biophysics, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.
出版信息
FEBS Lett. 2016 Jul;590(13):1940-54. doi: 10.1002/1873-3468.12118. Epub 2016 Mar 30.
Abstract
Influenza A virus (IAV) assembles on the plasma membrane where viral proteins localize to form a bud encompassing the viral genome, which ultimately pinches off to give rise to newly formed infectious virions. Upon entry, the virus faces the opposite task-fusion with the endosomal membrane and disassembly to deliver the viral genome to the cytoplasm. There are at least four influenza proteins-hemagglutinin (HA), neuraminidase (NA), matrix 1 protein (M1), and the M2 ion channel-that are known to directly interact with the cellular membrane and modify membrane curvature in order to both assemble and disassemble membrane-enveloped virions. Here, we summarize and discuss current knowledge of the interactions of lipids and membrane proteins involved in the IAV replication cycle.
摘要
甲型流感病毒（IAV）在质膜上组装，病毒蛋白在质膜上定位形成一个包裹病毒基因组的芽，最终芽被掐断形成新形成的感染性病毒粒子。进入细胞后，病毒面临着相反的任务——与内体膜融合并解体，将病毒基因组递送至细胞质。已知至少有四种流感病毒蛋白——血凝素（HA）、神经氨酸酶（NA）、基质1蛋白（M1）和M2离子通道——可直接与细胞膜相互作用并改变膜曲率，从而组装和解体包膜病毒粒子。在此，我们总结并讨论了目前关于参与IAV复制周期的脂质和膜蛋白相互作用的知识。
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