音乐家肌张力障碍中异常的半球间抑制——特质还是状态？
Abnormal interhemispheric inhibition in musician's dystonia - Trait or state?
作者信息
Bäumer Tobias, Schmidt Alexander, Heldmann Marcus, Landwehr Moritz, Simmer Anna, Tönniges Diana, Münte Thomas, Lohmann Katja, Altenmüller Eckart, Klein Christine, Münchau Alexander
机构信息
Department of Paediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany; Department of Neurology, University Medical Center Hamburg-Eppendorf, Martinistraße 52, 20246, Hamburg, Germany.
Institute of Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany; Kurt Singer Institute for Music Physiology and Musicians' Health, Hanns Eisler School of Music Berlin, Charlottenstr. 55, 10117, Berlin, Germany; Interdisciplinary Competence Center Musicians' Medicine, Charité - University Medicine Berlin, Luisenstr. 13, 1. OG, 10117, Berlin, Germany; Department of Neurology, University of Lübeck, Ratzeburger Allee 160, 23562, Lübeck, Germany.
出版信息
Parkinsonism Relat Disord. 2016 Apr;25:33-8. doi: 10.1016/j.parkreldis.2016.02.018. Epub 2016 Feb 20.
INTRODUCTION
A clustering of relatives with dystonia has been reported in families with musician's dystonia suggesting a genetic contribution to this disease. The aim of the present study was to determine whether interhemispheric inhibition (IHI) measured with transcranial magnetic stimulation is impaired in healthy family members rendering it a suitable endophenotypic marker for musician's dystonia.
METHODS
Patients with musician's hand dystonia (n = 21), patients with sporadic writer's cramp (n = 15), their healthy family members (n = 27), healthy musicians (n = 12) and healthy non-musicians (n = 12) were included. An extended interview about the family history and musical activity was performed. IHI in both hemispheres was measured using transcranial magnetic stimulation.
RESULTS
A stepwise regression analysis revealed musical activity (p = 0.001) and a family history of dystonia (p = 0.008) but not dystonia per se, age, handedness or gender as relevant factors modulating IHI.
CONCLUSION
These data support the notion of a genetic background of musician's hand dystonia and suggests that reduced IHI is a possible endophenotypic marker of this disorder.
引言
在患有音乐家肌张力障碍的家族中，有亲属聚集性发病的报道，提示该病存在遗传因素。本研究的目的是确定经颅磁刺激测量的半球间抑制（IHI）在健康家庭成员中是否受损，使其成为音乐家肌张力障碍合适的内表型标志物。
方法
纳入患有音乐家手部肌张力障碍的患者（n = 21）、散发性书写痉挛患者（n = 15）、他们的健康家庭成员（n = 27）、健康音乐家（n = 12）和健康非音乐家（n = 12）。进行了关于家族史和音乐活动的详细访谈。使用经颅磁刺激测量双侧半球的IHI。
结果
逐步回归分析显示，音乐活动（p = 0.001）和肌张力障碍家族史（p = 0.008），而非肌张力障碍本身、年龄、利手或性别，是调节IHI的相关因素。
结论
这些数据支持音乐家手部肌张力障碍存在遗传背景的观点，并表明IHI降低可能是该疾病的一种内表型标志物。
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