Cimitan A, Fantini F, Giannetti A
Department of Dermatology, University of Modena, Italy.
Acta Derm Venereol Suppl (Stockh). 1989;146:159-62; discussion 162-3. doi: 10.2340/0001555569146159163.
Six male patients with extensive psoriasis, resistant to conventional treatment, were treated orally with low-dose Cyclosporin A (CsA) (5 mg/kg/day). One patient had generalized pustular psoriasis, three psoriatic erythroderma, and two disseminated chronic plaque psoriasis. All patients, with the exception of one, were treated for at least twelve weeks. Nearly complete remission was obtained in four cases. In one patient the response was incomplete, while treatment in one case was suspended after two weeks because of the onset of cutaneous pyogenic infections and oral candidiasis. In each case a relapse was observed with the suspension of treatment.
六名患有广泛银屑病且对传统治疗耐药的男性患者接受了低剂量环孢素A（CsA）（5毫克/千克/天）口服治疗。一名患者患有泛发性脓疱型银屑病，三名患者患有银屑病红皮病，两名患者患有播散性慢性斑块状银屑病。除一名患者外，所有患者均接受了至少十二周的治疗。四例患者获得了近乎完全缓解。一名患者的反应不完全，而另一例患者在两周后因皮肤化脓性感染和口腔念珠菌病发作而中止治疗。在每种情况下，治疗中止后均观察到复发。
