环孢素A在重度银屑病中的短期应用。

Short-term use of cyclosporin A in severe psoriasis.

作者信息

Van Joost T, Heule F, Stolz E, Beukers R

出版信息

Br J Dermatol. 1986 May;114(5):615-20. doi: 10.1111/j.1365-2133.1986.tb04070.x.

DOI:10.1111/j.1365-2133.1986.tb04070.x

Abstract

The effectiveness of cyclosporin A (CyA) in low dosages (mean 5 mg/kg/day) for short-term treatment of severe psoriasis was studied. Of five patients with severe progressive psoriasis vulgaris (mean PASI score 43.8), an almost complete remission in three patients, and a large reduction in PASI score in the remaining two patients, was obtained within 4 weeks. No important clinical side-effects were found but there was biochemical evidence of slight renal dysfunction in one patient. The mean percentage reduction in the PASI score was 84%. It was concluded that the results reported justify further study of the use of CyA in the treatment of severe psoriasis.

摘要

研究了低剂量（平均5毫克/千克/天）环孢素A（CyA）短期治疗重度银屑病的有效性。在5例重度进行性寻常型银屑病患者中（平均银屑病面积和严重程度指数（PASI）评分为43.8），3例患者几乎完全缓解，其余2例患者的PASI评分大幅降低，均在4周内实现。未发现重要的临床副作用，但有生化证据表明1例患者存在轻微肾功能不全。PASI评分的平均降低百分比为84%。得出的结论是，所报告的结果证明有必要进一步研究CyA在重度银屑病治疗中的应用。