Palmer Allyson K, Kirkland James L
Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA.
Exp Gerontol. 2016 Dec 15;86:97-105. doi: 10.1016/j.exger.2016.02.013. Epub 2016 Feb 26.
Adipose tissue dysfunction occurs with aging and has systemic effects, including peripheral insulin resistance, ectopic lipid deposition, and inflammation. Fundamental aging mechanisms, including cellular senescence and progenitor cell dysfunction, occur in adipose tissue with aging and may serve as potential therapeutic targets in age-related disease. In this review, we examine the role of adipose tissue in healthy individuals and explore how aging leads to adipose tissue dysfunction, redistribution, and changes in gene regulation. Adipose tissue plays a central role in longevity, and interventions restricted to adipose tissue may impact lifespan. Conversely, obesity may represent a state of accelerated aging. We discuss the potential therapeutic potential of targeting basic aging mechanisms, including cellular senescence, in adipose tissue, using type II diabetes and regenerative medicine as examples. We make the case that aging should not be neglected in the study of adipose-derived stem cells for regenerative medicine strategies, as elderly patients make up a large portion of individuals in need of such therapies.
脂肪组织功能障碍随着衰老而出现，并具有全身影响，包括外周胰岛素抵抗、异位脂质沉积和炎症。包括细胞衰老和祖细胞功能障碍在内的基本衰老机制随着衰老在脂肪组织中发生，并且可能成为与年龄相关疾病的潜在治疗靶点。在本综述中，我们研究了脂肪组织在健康个体中的作用，并探讨衰老如何导致脂肪组织功能障碍、重新分布以及基因调控变化。脂肪组织在长寿中起着核心作用，而仅限于脂肪组织的干预措施可能会影响寿命。相反，肥胖可能代表一种加速衰老的状态。我们以2型糖尿病和再生医学为例，讨论针对脂肪组织中包括细胞衰老在内的基本衰老机制的潜在治疗潜力。我们认为，在用于再生医学策略的脂肪干细胞研究中，衰老不应被忽视，因为老年患者在需要此类治疗的人群中占很大比例。
