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福岛甲状腺超声检查的方案及初步基线调查结果[快速通讯]

The protocol and preliminary baseline survey results of the thyroid ultrasound examination in Fukushima [Rapid Communication].

作者信息

Suzuki Shinichi, Yamashita Shunichi, Fukushima Toshihiko, Nakano Keiichi, Midorikawa Sanae, Ohtsuru Akira, Yasumura Seiji, Hosoya Mitsunori, Kamiya Kenji, Shimura Hiroki, Suzuki Satoru, Nakamura Izumi, Abe Masafumi

机构信息

Department of Thyroid and Endocrinology, Fukushima Medical University School of Medicine, Fukushima 960-1295, Japan.

出版信息

Endocr J. 2016;63(3):315-21. doi: 10.1507/endocrj.EJ15-0726. Epub 2016 Feb 27.

Abstract

UNLABELLED

After the Fukushima nuclear power plant accident on March 11, 2011, the public of Japan became particularly concerned about the possibility of an increased risk of childhood thyroid cancer, similar to what was observed after the Chernobyl's accident. Due to serious public health perception, there was an urgency to evaluate the baseline levels of childhood thyroid status in Fukushima prefecture. Therefore we have commenced a thyroid ultrasound examination (TUE) survey of the approximately 360,000 pediatric inhabitants (0 to 18 years of age) who lived in Fukushima at the time of the accident in October 2011. The subjects were divided into three categories according to the standardized diagnostic criteria of ultrasound findings. Category A contained the subjects whose TUE findings were intact or benign. Category B were recommended a confirmatory TUE. Category C was recommended an immediate confirmatory TUE.

RESULTS

The survey of 40,302 subjects in the first year was completed in March, 2013. There were 40,097 (99.5%), 205 (0.50%) and 0 subjects in categories A, B and C, respectively. Of the 82 category B subjects who underwent fine needle aspiration cytology (FNAC), 12 were diagnosed with a malignant tumor or were suspected to have malignancy. The 12 subjects received thyroid surgery and 11 thyroid cancers and one benign nodule were confirmed histologically after surgery. This is the first large-scaled TUE survey to employ sophisticated ultrasound screening and aim to evaluate the baseline frequency of childhood thyroid nodules and cysts. The results will become the golden standard of future comparative TUE in Fukushima, Japan.

摘要

未标注

2011年3月11日福岛核电站事故后,日本公众特别关注儿童甲状腺癌风险增加的可能性,这与切尔诺贝利事故后观察到的情况类似。由于严重的公众健康认知,迫切需要评估福岛县儿童甲状腺状况的基线水平。因此,我们于2011年10月对事故发生时居住在福岛的约36万名儿童居民(0至18岁)开始了甲状腺超声检查(TUE)调查。根据超声检查结果的标准化诊断标准,将受试者分为三类。A类包括TUE检查结果正常或为良性的受试者。B类被建议进行确认性TUE检查。C类被建议立即进行确认性TUE检查。

结果

第一年对40302名受试者的调查于2013年3月完成。A、B、C类受试者分别有40097名(99.5%)、205名(0.50%)和0名。在接受细针穿刺细胞学检查(FNAC)的82名B类受试者中,12名被诊断为恶性肿瘤或疑似患有恶性肿瘤。这12名受试者接受了甲状腺手术,术后经组织学确认有11例甲状腺癌和1例良性结节。这是首次采用精密超声筛查并旨在评估儿童甲状腺结节和囊肿基线频率的大规模TUE调查。该结果将成为日本福岛未来比较性TUE的黄金标准。

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