产前暴露于抗抑郁药和未经药物治疗的抑郁症患儿的行为与抑制控制
Behavior and inhibitory control in children with prenatal exposure to antidepressants and medically untreated depression.
作者信息
Hermansen Tone Kristine, Røysamb Espen, Augusti Else-Marie, Melinder Annika
机构信息
The Cognitive Developmental Research Unit, Department of Psychology, University of Oslo, Forskningsveien 3a, 0373, Oslo, Norway.
The Norwegian Institute of Public Health, Oslo, Norway.
出版信息
Psychopharmacology (Berl). 2016 Apr;233(8):1523-35. doi: 10.1007/s00213-016-4248-3. Epub 2016 Feb 29.
PURPOSE
The present study investigates child development following prenatal exposure to maternal use of selective serotonin reuptake inhibitors (SSRIs; N = 28), versus prenatal exposure to medically untreated depression (N = 42), and no exposure (N = 33).
METHODS
When the children reached 5-6 years of age, child cognitive abilities were measured using selected tests from Wechsler Preschool and Primary Scale of Intelligence-Revised (WPPSI-r), Neuropsychological Assessment II (NEPSY-II), and the Attention Network Test. Maternal reports of child behavioral problems were collected using the Child Behavior Checklist (CBCL).
CONCLUSION
Analyses of variance revealed no effects of prenatal exposure to depression or SSRIs upon general cognition or inhibition. Regarding behavioral problems, there was a significant negative association between both SSRI and depression exposure upon externalizing, and between SSRI exposure and internalizing problems. The results are interpreted in light of theories on interactive specialization and reactivity.
目的
本研究调查产前暴露于母亲使用选择性5-羟色胺再摄取抑制剂（SSRIs；n = 28）、产前暴露于未经药物治疗的抑郁症（n = 42）以及未暴露（n = 33）情况下儿童的发育情况。
方法
当儿童达到5 - 6岁时，使用韦氏学前及初小儿童智力测验修订版（WPPSI - r）、神经心理评估II（NEPSY-II）以及注意力网络测试中的特定测试来测量儿童的认知能力。使用儿童行为清单（CBCL）收集母亲关于儿童行为问题的报告。
结论
方差分析显示，产前暴露于抑郁症或SSRIs对一般认知或抑制能力没有影响。关于行为问题，SSRI暴露和抑郁症暴露与外化问题之间均存在显著负相关，且SSRI暴露与内化问题之间也存在显著负相关。研究结果根据交互专业化和反应性理论进行了解释。
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