Zhao Bizeng, Zhang Wei, Du Shengchao, Zhou Zubin
Department of Orthopedics, Shanghai 6 People's Hospital of Shanghai Jiaotong University, Shanghai, China.
Arch Med Sci. 2016 Feb 1;12(1):25-30. doi: 10.5114/aoms.2016.57475. Epub 2016 Jan 27.
Many studies have suggested that the vitamin D receptor polymorphism BsmI might be associated with the risk of osteoporosis development in post-menopausal women. However, the results have been inconsistent. The aim of this meta-analysis was to derive a more precise evaluation of the relationship.
Published literature from PubMed, EMBASE and the CNKI database was searched. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of any association.
Ten case-control studies were included with a total of 1,403 osteoporosis cases and 2,144 healthy controls. In the overall analysis, no significant association was found between BsmI polymorphism and osteoporosis risk (BB vs. bb: OR = 0.76, 95% CI = 0.39-1.48; BB vs. Bb: OR = 0.90, 95% CI = 0.71-1.15; dominant model: OR = 1.20, 95% CI = 0.74-1.93; recessive model: OR = 0.83, 95% CI = 0.53-1.30). In the subgroup analysis by ethnicity, the results showed similar result that BsmI polymorphism m had no association with osteoporosis.
Results from the current meta-analysis suggest that vitamin D receptor BsmI polymorphism may not be a risk factor for osteoporosis in post-menopausal women.
许多研究表明，维生素D受体基因多态性BsmI可能与绝经后女性患骨质疏松症的风险有关。然而，结果并不一致。本荟萃分析的目的是对这种关系进行更精确的评估。
检索了来自PubMed、EMBASE和中国知网数据库的已发表文献。采用粗比值比（OR）及95%置信区间（CI）评估关联强度。
纳入10项病例对照研究，共1403例骨质疏松症病例和2144例健康对照。在总体分析中，未发现BsmI基因多态性与骨质疏松症风险之间存在显著关联（BB与bb：OR = 0.76，95% CI = 0.39 - 1.48；BB与Bb：OR = 0.90，95% CI = 0.71 - 1.15；显性模型：OR = 1.20，95% CI = 0.74 - 1.93；隐性模型：OR = 0.83，95% CI = 0.53 - 1.30）。在按种族进行的亚组分析中，结果显示BsmI基因多态性与骨质疏松症无关联，结果相似。
当前荟萃分析结果表明，维生素D受体BsmI基因多态性可能不是绝经后女性骨质疏松症的危险因素。
