Lyons M Melanie, Bhatt Nitin Y, Kneeland-Szanto Elizabeth, Keenan Brendan T, Pechar Joanne, Stearns Branden, Elkassabany Nabil M, Memtsoudis Stavros G, Pack Allan I, Gurubhagavatula Indira
Division of Sleep Medicine, Center for Sleep & Circadian Neurobiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Biobehavioral Research, School of Nursing, University of Pennsylvania, Philadelphia, PA, USA.
Biomark Med. 2016;10(3):265-300. doi: 10.2217/bmm.16.1.
Obstructive sleep apnea (OSA) is highly prevalent in patients undergoing total joint arthroplasty (TJA) and is a major risk factor for postoperative cardiovascular complications and death. Recognizing this, the American Society of Anesthesiologists urges clinicians to implement special considerations in the perioperative care of OSA patients. However, as the volume of patients presenting for TJA increases, resources to implement these recommendations are limited. This necessitates mechanisms to efficiently risk stratify patients having OSA who may be susceptible to post-TJA cardiovascular complications. We explore the role of perioperative measurement of cardiac troponins (cTns) and brain natriuretic peptides (BNPs) in helping determine which OSA patients are at increased risk for post-TJA cardiovascular-related morbidity.
阻塞性睡眠呼吸暂停(OSA)在接受全关节置换术(TJA)的患者中非常普遍,并且是术后心血管并发症和死亡的主要危险因素。认识到这一点,美国麻醉医师协会敦促临床医生在OSA患者的围手术期护理中采取特殊考虑。然而,随着接受TJA的患者数量增加,实施这些建议的资源有限。这就需要有机制来有效地对可能易患TJA后心血管并发症的OSA患者进行风险分层。我们探讨围手术期测量心肌肌钙蛋白(cTn)和脑钠肽(BNP)在帮助确定哪些OSA患者发生TJA后心血管相关发病率增加风险方面的作用。