Kaur Manpreet, Kaur Tarnjeet, Kamboj Sukhdev Singh, Singh Jatinder
1Department of Human Genetics, Guru Nanak Dev University, Amritsar, India E-mail :
Asian Pac J Cancer Prev. 2016;17(2):455-61. doi: 10.7314/apjcp.2016.17.2.455.
Galectins are β-galactoside binding lectins that contain one or more carbohydrate recognition domains. As a consequence of sugar-binding properties, galectins exhibit a variety of interactions with glycoproteins, thus playing important roles in various pathological processes. A number of studies have shown roles of galectins in cancer. Galectin-7 is a prototype member of the galectin family implicated in epithelial stratification and cell migration. It can act as a potent dual regulator in different types of cancer. Galectin-7 may contribute either to neoplastic transformation and tumour progression through regulation of cell growth, cell cycle, angiogenesis, apoptosis and cell migration or may have a protective effect in cancer depending on the tissue type. A perusal of the literature indicates particular roles of galectin-7 in carcinomas and melanomas, while contributions await greater exploration in other types of cancers including sarcomas and leukemia. This review collectively summarizes available literature on expression and roles of galectin-7 in different cancers.
半乳糖凝集素是一类结合β-半乳糖苷的凝集素，含有一个或多个碳水化合物识别结构域。由于其糖结合特性，半乳糖凝集素与糖蛋白表现出多种相互作用，从而在各种病理过程中发挥重要作用。许多研究表明半乳糖凝集素在癌症中发挥作用。半乳糖凝集素-7是半乳糖凝集素家族的一个原型成员，与上皮分层和细胞迁移有关。它可以在不同类型的癌症中作为一种有效的双重调节因子。半乳糖凝集素-7可能通过调节细胞生长、细胞周期、血管生成、细胞凋亡和细胞迁移促进肿瘤转化和肿瘤进展，也可能根据组织类型在癌症中发挥保护作用。查阅文献表明半乳糖凝集素-7在 carcinomas 和黑色素瘤中具有特殊作用，而在包括肉瘤和白血病在内的其他类型癌症中的作用还有待进一步探索。本综述共同总结了关于半乳糖凝集素-7在不同癌症中的表达和作用的现有文献。
