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马来西亚哥打士打和瓜拉慕达地区结直肠癌筛查项目评估

Evaluation of a Colorectal Carcinoma Screening Program in Kota Setar and Kuala Muda Districts, Malaysia.

作者信息

Abu Hassan Muhammad Radzi, Leong Tan Wei, Othman Andu Delarina Frimawati, Hat Habshoh, Nik Mustapha Nik Raihan

机构信息

Clinical Research Centre, Sultanah Bahiyah Hospital , Alor Setar, Malaysia E-mail :

出版信息

Asian Pac J Cancer Prev. 2016;17(2):569-73. doi: 10.7314/apjcp.2016.17.2.569.

Abstract

BACKGROUND

A colorectal cancer screening program was piloted in two districts of Kedah in 2013. There is scarcity of information on colorectal cancer screening in Malaysia.

OBJECTIVE

Thus, this research was conducted to evaluate the colorectal cancer screening program in the districts to provide insights intop its efficacy.

MATERIALS AND METHODS

A cross sectional study was conducted using data on the colorectal cancer screening program in 2013 involving Kota Setar and Kuala Muda districts in Malaysia. We determined the response rate of immunochemical fecal occult blood test (iFOBT), colonoscopy compliance, and detection rates of neoplasia and carcinoma. We also compared the response of FOBT by demographic background.

RESULTS

The response rate of FOBT for first iFOBT screening was 94.7% while the second iFOBT screening was 90.7%. Participants from Kuala Muda district were 27 times more likely to default while Indians had a 3 times higher risk of default compared to Malays. The colonoscopy compliance was suboptimal among those with positive iFOBT. The most common finding from colonoscopy was hemorrhoids, followed by tubular adenoma. Detection rate of carcinoma and neoplasia for our program was 1.2%.

CONCLUSIONS

In summary, the response rate of iFOBT was encouraging but the colonoscopy compliance was suboptimal which led to a considerably low detection rate.

摘要

背景

2013年在吉打州的两个地区开展了结直肠癌筛查项目。马来西亚关于结直肠癌筛查的信息匮乏。

目的

因此,开展本研究以评估这些地区的结直肠癌筛查项目,从而深入了解其效果。

材料与方法

采用2013年马来西亚吉打州和瓜拉慕达地区结直肠癌筛查项目的数据进行横断面研究。我们确定了免疫化学粪便潜血试验(iFOBT)的应答率、结肠镜检查依从性以及瘤变和癌的检出率。我们还按人口统计学背景比较了FOBT的应答情况。

结果

首次iFOBT筛查的FOBT应答率为94.7%,第二次iFOBT筛查为90.7%。瓜拉慕达地区的参与者违约可能性是其他地区的27倍,而印度人违约风险比马来人高3倍。iFOBT呈阳性者的结肠镜检查依从性欠佳。结肠镜检查最常见的结果是痔疮,其次是管状腺瘤。我们项目的癌和瘤变检出率为1.2%。

结论

总之,iFOBT的应答率令人鼓舞,但结肠镜检查依从性欠佳,导致检出率相当低。

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