Girgis Fady, Miller Jonathan P
Department of Neurosurgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, United States of America.
Department of Neurosurgery, University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, OH, United States of America.
Seizure. 2016 Apr;37:28-31. doi: 10.1016/j.seizure.2016.02.004. Epub 2016 Feb 19.
Electrical stimulation in the treatment of epilepsy has been tried in numerous forms and with a variety of targets. Some of these, such as anterior thalamic stimulation, responsive cortical stimulation, and vagal nerve stimulation, have shown promise. A relatively novel concept, that of white matter stimulation, offers a different mechanism in that a small population of stimulated axons can transmit current to a large population of epileptogenic neurons. In theory, this allows for the modulation of seizure circuits and neural networks using lower stimulation volumes. Although clinical data is currently sparse, we review the relevant studies pertaining to white matter stimulation in epilepsy thus far, and offer explanations as to its effects, potential advantages, and utility.
电刺激治疗癫痫已经尝试了多种形式和多种靶点。其中一些，如丘脑前核刺激、皮层反应性刺激和迷走神经刺激，已显示出前景。一个相对新颖的概念，即白质刺激，提供了一种不同的机制，因为一小部分受刺激的轴突可以将电流传递给大量致痫神经元。理论上，这允许使用较低的刺激量来调节癫痫发作环路和神经网络。尽管目前临床数据稀少，但我们回顾了迄今为止与癫痫白质刺激相关的研究，并对其作用、潜在优势和实用性进行了解释。
