Rosas-Cabral Alejandro, Viana-Rojas Jesús Antonio, Prieto-Macías Jorge, del Carmen Terrones-Saldívar María, Gutiérrez-Campos Rafael, Ponce-Campos Silvia Denise, de Jesús de Lara-Castañeda José
Departamento de Medicina, Universidad Autónoma de Aguascalientes, Aguascalientes, Ags., México.
Servicio de Medicina Crítica, Hospital General de Zona N.o 1, IMSS, Aguascalientes, Ags., México.
Gac Med Mex. 2016 Jan-Feb;152(1):70-7.
To demonstrate the association between red cell distribution width and short-term mortality risk in patients with acute coronary syndrome.
We prospectively recruited 78 patients with acute coronary syndrome. The study population was classified according to quartiles of the red cell distribution width at hospital admission. A high red cell distribution width was defined as a value in the upper fourth quartile (>15) and a low red cell distribution width was defined as any value set in the lower three quartiles (≤15). After discharge, all patients were followed for three months.
The short-term cardiovascular mortality was 47.2% in the high red cell distribution width group vs. 10.2% in the low red cell distribution width group (p<0.001). In the receiver operating characteristic curve analysis, a red cell distribution width value of more than 15% yielded a sensitivity of 66.7%, a specificity of 83%, and a positive predictive value of 79.7% for cardiac mortality. After multivariate analysis, high levels of red cell distribution width were independent predictors for three-month mortality (p=0.001).
We demonstrated that red cell distribution width is an accessible parameter associated with short-term cardiovascular mortality in patients with acute coronary syndrome.
探讨急性冠状动脉综合征患者红细胞分布宽度与短期死亡风险之间的关联。
前瞻性招募78例急性冠状动脉综合征患者。根据入院时红细胞分布宽度的四分位数对研究人群进行分类。红细胞分布宽度高定义为处于上四分位数（>15），红细胞分布宽度低定义为处于下三个四分位数中的任何值（≤15）。出院后，对所有患者进行为期三个月的随访。
红细胞分布宽度高的组短期心血管死亡率为47.2%，而红细胞分布宽度低的组为10.2%（p<0.001）。在受试者工作特征曲线分析中，红细胞分布宽度值超过15%时，对心脏死亡的敏感性为66.7%，特异性为83%，阳性预测值为79.7%。多因素分析后，红细胞分布宽度高水平是三个月死亡率的独立预测因素（p=0.001）。
我们证明红细胞分布宽度是急性冠状动脉综合征患者短期心血管死亡率的一个可获取的相关参数。
