Duran Mustafa, Uysal Onur Kadir, Günebakmaz Ozgür, Yılmaz Yücel, Akın Fatih, Baran Oğuzhan, Inanç Mehmet Tuğrul, Eryol Namık Kemal, Ergin Ali, Oğuzhan Abdurrahman, Kaya Mehmet Güngör
Department of Cardiology, Kayseri Training and Research Hospital, Kayseri, Turkey.
Turk Kardiyol Dern Ars. 2013 Jul;41(5):399-405. doi: 10.5543/tkda.2013.86244.
Several studies have evaluated a relationship between increased red cell distribution width (RDW) and morbidity and mortality of acute coronary syndrome (ACS). In this study, we aimed to investigate the association of serum RDW levels and development of coronary collateral vessel (CCV) in patients with ACS.
We evaluated 226 patients with ACS in this prospective and cross-sectional study. Traditional laboratory and clinical parameters and serum RDW levels were measured on admission. All patients underwent coronary angiography on the first day after admission and patients with >80% stenosis were included in the study. The CCV was graded according to the Rentrop scoring system, and a Rentrop grade 0 was accepted as no CCV development (Group 1), while Rentrop grades 1-2-3 were accepted as presence of CCV development (Group 2).
Only levels of RDW were significantly higher in Group 1 than in Group 2 (Group 1 RDW 14.6±1.9, Group 2 RDW 14.1±1.4, p=0.02). The predictive value of serum RDW level for absence of collaterals (sensitivity of 58% and specificity of 54%, area under the receiver operating characteristic (ROC) curve = 0.573) was 13.90.
We found that high levels of RDW were associated with absence of CCV in patients with ACS.
多项研究评估了红细胞分布宽度（RDW）增加与急性冠状动脉综合征（ACS）的发病率和死亡率之间的关系。在本研究中，我们旨在调查ACS患者血清RDW水平与冠状动脉侧支血管（CCV）形成之间的关联。
在这项前瞻性横断面研究中，我们评估了226例ACS患者。入院时测量传统实验室和临床参数以及血清RDW水平。所有患者在入院后第一天接受冠状动脉造影，狭窄>80%的患者纳入研究。CCV根据Rentrop评分系统分级，Rentrop 0级被视为无CCV形成（第1组），而Rentrop 1-2-3级被视为有CCV形成（第2组）。
仅第1组的RDW水平显著高于第2组（第1组RDW 14.6±1.9，第2组RDW 14.1±1.4，p=0.02）。血清RDW水平对无侧支血管的预测价值（敏感性为58%，特异性为54%，受试者工作特征（ROC）曲线下面积=0.573）为13.90。
我们发现，ACS患者中RDW水平升高与无CCV相关。
