Dwivedi Nitin, Shah Jigna, Mishra Vijay, Mohd Amin Mohd Cairul Iqbal, Iyer Arun K, Tekade Rakesh Kumar, Kesharwani Prashant
a Pharmacology Research Laboratory, Institute of Pharmacy , Nirma University , Ahmedabad , India.
b Pharmaceutical Nanotechnology Research Laboratory , Adina Institute of Pharmaceutical Sciences , Sagar , India.
J Biomater Sci Polym Ed. 2016;27(7):557-80. doi: 10.1080/09205063.2015.1133155. Epub 2016 Feb 29.
Worldwide, the cancer appeared as one of the most leading cause of morbidity and mortality. Among the various cancer types, brain tumors are most life threatening with low survival rate. Every year approximately 238,000 new cases of brain and other central nervous system tumors are diagnosed. The dendrimeric approaches have a huge potential for diagnosis and treatment of brain tumor with targeting abilities of molecular cargoes to the tumor sites and the efficiency of crossing the blood brain barrier and penetration to brain after systemic administration. The various generations of dendrimers have been designed as novel targeted drug delivery tools for new therapies including sustained drug release, gene therapy, and antiangiogenic activities. At present era, various types of dendrimers like PAMAM, PPI, and PLL dendrimers validated them as milestones for the treatment and diagnosis of brain tumor as well as other cancers. This review highlights the recent research, opportunities, advantages, and challenges involved in development of novel dendrimeric complex for the therapy of brain tumor.
在全球范围内，癌症是发病率和死亡率最高的主要原因之一。在各种癌症类型中，脑肿瘤对生命威胁最大，生存率很低。每年大约有238,000例新发脑及其他中枢神经系统肿瘤被诊断出来。树枝状聚合物方法在脑肿瘤的诊断和治疗方面具有巨大潜力，其分子载药能够靶向肿瘤部位，并且在全身给药后具有穿越血脑屏障并渗透到脑内的效率。不同代数的树枝状聚合物已被设计为新型靶向药物递送工具，用于包括持续药物释放、基因治疗和抗血管生成活性在内的新疗法。在当今时代，各种类型的树枝状聚合物，如聚酰胺-胺（PAMAM）、聚哌嗪酰胺（PPI）和聚赖氨酸（PLL）树枝状聚合物，已被证实是脑肿瘤以及其他癌症治疗和诊断的里程碑。本综述重点介绍了新型树枝状聚合物复合物用于脑肿瘤治疗的最新研究、机遇、优势和挑战。
