Quirk S E, Stuart A L, Brennan-Olsen S L, Pasco J A, Berk M, Chanen A M, Koivumaa-Honkanen H, Kotowicz M A, Lukkala P S, Williams L J
Deakin University, IMPACT Strategic Research Centre, School of Medicine, Geelong, Australia.
Deakin University, IMPACT Strategic Research Centre, School of Medicine, Geelong, Australia.
Eur Psychiatry. 2016 Apr;34:29-35. doi: 10.1016/j.eurpsy.2015.12.007. Epub 2016 Feb 27.
Associations between common psychiatric disorders, psychotic disorders and physical health comorbidities are frequently investigated. The complex relationship between personality disorders (PDs) and physical health is less understood, and findings to date are varied. This study aims to investigate associations between PDs with a number of prevalent physical health conditions.
This study examined data collected from women (n=765;≥ 25 years) participating in a population-based study located in south-eastern Australia. Lifetime history of psychiatric disorders was assessed using the semi-structured clinical interviews (SCID-I/NP and SCID-II). The presence of physical health conditions (lifetime) were identified via a combination of self-report, medical records, medication use and clinical data. Socioeconomic status, and information regarding medication use, lifestyle behaviors, and sociodemographic information was collected via questionnaires. Logistic regression models were used to investigate associations.
After adjustment for sociodemographic variables (age, socioeconomic status) and health-related factors (body mass index, physical activity, smoking, psychotropic medication use), PDs were consistently associated with a range of physical health conditions. Novel associations were observed between Cluster A PDs and gastro-oesophageal reflux disease (GORD); Cluster B PDs with syncope and seizures, as well as arthritis; and Cluster C PDs with GORD and recurrent headaches.
PDs were associated with physical comorbidity. The current data contribute to a growing evidence base demonstrating associations between PDs and a number of physical health conditions independent of psychiatric comorbidity, sociodemographic and lifestyle factors. Longitudinal studies are now required to investigate causal pathways, as are studies determining pathological mechanisms.
常见精神障碍、精神分裂症与身体健康合并症之间的关联经常被研究。人格障碍（PDs）与身体健康之间的复杂关系则较少被理解，且目前的研究结果各不相同。本研究旨在调查PDs与多种常见身体健康状况之间的关联。
本研究检查了从参与澳大利亚东南部一项基于人群的研究的女性（n = 765；≥25岁）中收集的数据。使用半结构化临床访谈（SCID-I/NP和SCID-II）评估精神障碍的终生病史。通过自我报告、病历、药物使用和临床数据相结合的方式确定身体健康状况（终生）。通过问卷收集社会经济状况以及有关药物使用、生活方式行为和社会人口统计学信息。使用逻辑回归模型来研究关联。
在对社会人口统计学变量（年龄、社会经济状况）和健康相关因素（体重指数、身体活动、吸烟、精神药物使用）进行调整后，PDs与一系列身体健康状况始终相关。观察到A类PDs与胃食管反流病（GORD）之间存在新的关联；B类PDs与晕厥、癫痫以及关节炎有关；C类PDs与GORD和复发性头痛有关。
PDs与身体合并症有关。目前的数据有助于增加证据基础，证明PDs与多种身体健康状况之间存在关联，且独立于精神合并症、社会人口统计学和生活方式因素。现在需要进行纵向研究来调查因果途径，以及确定病理机制的研究。
