Tedder Jacqui, Miller Laurie, Tu Sicong, Hornberger Michael, Lah Suncica
a School of Psychology, University of Sydney , Sydney , Australia.
b ARC Centre of Excellence in Cognition and its Disorders , Sydney , Australia.
Clin Neuropsychol. 2016 Feb;30(2):351-66. doi: 10.1080/13854046.2016.1142612. Epub 2016 Feb 29.
Remembering the past and imaging the future are both manifestations of 'mental time travel'. These processes have been found to be impaired in patients with bilateral hippocampal lesions. Here, we examined the question of whether future thinking is affected by other Papez circuit lesions, namely: damage to the mammillary bodies/fornix.
Case (SL) was a 43-year-old woman who developed dense anterograde and retrograde amnesia suddenly, as a result of Wernicke-Korsakoff's syndrome. A region of interest volumetric Magnetic resonance imaging (MRI) analysis was performed. We assessed past and future thinking in SL and 11 control subjects of similar age and education with the adapted Autobiographical Interview (AI). Participants also completed a battery of neuropsychological tests.
Volumetric MRI analyses revealed severely reduced fornix and mammillary body volumes, but intact hippocampi. SL showed substantial, albeit temporally graded retrograde memory deficits on the adapted AI. Strikingly, whilst SL could not provide any specific details of events from the past two weeks or past two years and had impaired recall of events from her late 30s, her descriptions of potential future events were normal in number of event details and plausibility.
This dissociation of past and future events' performance after mammillary body and fornix damage is at odds with the findings of the majority of patients with adult onset hippocampal amnesia. It suggests that these non-hippocampal regions of the Papez circuit are only critical for past event retrieval and not for the generation of possible future events.
回忆过去和想象未来都是“心理时间旅行”的表现形式。已发现双侧海马体损伤的患者这些过程受损。在此，我们研究了未来思维是否会受到其他帕佩兹回路损伤的影响，即：乳头体/穹窿受损。
病例（SL）是一名43岁女性，因韦尼克 - 科尔萨科夫综合征突然出现严重的顺行性和逆行性失忆。进行了感兴趣区域的容积磁共振成像（MRI）分析。我们使用改编后的自传体访谈（AI）评估了SL以及11名年龄和教育程度相似的对照受试者的过去和未来思维。参与者还完成了一系列神经心理学测试。
容积MRI分析显示穹窿和乳头体体积严重减小，但海马体完好。在改编后的AI上，SL表现出明显的、尽管有时间梯度的逆行性记忆缺陷。令人惊讶的是，虽然SL无法提供过去两周或过去两年事件的任何具体细节，并且对她30多岁后期的事件回忆受损，但她对潜在未来事件的描述在事件细节数量和合理性方面是正常的。
乳头体和穹窿受损后过去和未来事件表现的这种分离与大多数成年后发生海马体失忆症患者的研究结果不一致。这表明帕佩兹回路的这些非海马体区域仅对过去事件的检索至关重要，而对可能的未来事件的产生并不重要。
