Translational Research Center for Protein Function Control, Yonsei University, Seoul, Korea.
Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul, Korea.
Phytother Res. 2016 May;30(5):848-54. doi: 10.1002/ptr.5593. Epub 2016 Mar 1.
Polygonum aviculare L. is a member of the Polygonaceae family of plants, which has been known for its antioxidant and anti-obesity effects. However, the wound healing function of P. aviculare extract has not been assessed. In this study, we identified a novel property of P. aviculare extract as a Wnt/β-catenin pathway activator based on a screen of 350 plant extracts using HEK293-TOP cells retaining the Wnt/β-catenin signaling reporter gene. P. aviculare extract accelerated the migration of HaCaT keratinocytes without showing significant cytotoxicity. Moreover, P. aviculare extract efficiently re-epithelized wounds generated on mice. Additionally, ingredients of P. aviculare extract, such as quercitrin hydrate, caffeic acid, and rutin, also accelerated the motility of HaCaT keratinocytes with the activation of Wnt/β-catenin signaling. Therefore, based on our findings, P. aviculare extract and its active ingredients could be potential therapeutic agents for wound healing. Copyright © 2016 John Wiley & Sons, Ltd.
菰根 L. 是蓼科植物的一员，具有抗氧化和抗肥胖作用。然而，菰根提取物的伤口愈合功能尚未得到评估。在这项研究中，我们通过使用保留 Wnt/β-连环蛋白信号报告基因的 HEK293-TOP 细胞筛选 350 种植物提取物，发现菰根提取物是 Wnt/β-连环蛋白途径的激活剂，具有一种新的特性。菰根提取物可加速 HaCaT 角质形成细胞的迁移，而没有表现出明显的细胞毒性。此外，菰根提取物可有效再上皮化在小鼠上生成的伤口。此外，菰根提取物的成分，如槲皮素水合物、咖啡酸和芦丁，也通过激活 Wnt/β-连环蛋白信号加速 HaCaT 角质形成细胞的运动。因此，基于我们的发现，菰根提取物及其有效成分可能是伤口愈合的潜在治疗剂。版权所有© 2016 约翰威立父子公司
