Jayaraman Srinivasan
Department of Prosthodontics, Indira Gandhi Institute of Dental Sciences, Sri Balaji Vidyapeeth University, Puducherry, India.
J Indian Prosthodont Soc. 2015 Apr-Jun;15(2):179-82. doi: 10.4103/0972-4052.159974.
The failure of dental implant can occurs at the preoperative planning stage, at the surgical stage, and at the postoperative stage. The success of this treatment can be increased if the clinical implant practice guidelines are prepared based on the recommendations from the highest level of research evidence (i.e.,) from systematic review of randomized controlled trials (RCTs) with meta-analysis. The Cochrane reviews of interventions are basically systematic reviews of RCTs with meta-analysis but follow a systematic methodological approach following the guidelines from Cochrane handbook for Systematic Reviews of Intervention. They give the current best evidence as they are updated every 2 years which is being the minimum period for an update. This evidence summary recommends the use of antibiotics, single dose of 2 g of amoxicillin 1 h prior to implant surgery to prevent implant failure, based on the body of evidence from the Cochrane review that was first published in 2003, 2008, and then updated twice in 2010 and 2013. The included studies are not from our population for the research question asked in this updated Cochrane review; hence, the need to do primary research in our population to support the available evidence is mandatory.
牙种植体失败可能发生在术前规划阶段、手术阶段和术后阶段。如果根据最高水平的研究证据（即对随机对照试验（RCT）进行系统评价并进行荟萃分析）制定临床种植实践指南，这种治疗的成功率可以提高。Cochrane干预评价基本上是对RCT进行系统评价并进行荟萃分析，但遵循《Cochrane干预系统评价手册》的指南采用系统的方法学途径。它们提供了当前最佳证据，因为每两年更新一次，这是更新的最短期限。基于2003年、2008年首次发表并于2010年和2013年两次更新的Cochrane评价的证据，本证据总结建议在种植手术前1小时使用抗生素，单次服用2克阿莫西林以预防种植体失败。纳入的研究并非来自本次更新的Cochrane评价所提出研究问题的目标人群；因此，有必要在我们的人群中开展原始研究以支持现有证据。
