Gynther G W, Köndell P A, Moberg L E, Heimdahl A
Department of Oral and Maxillofacial Surgery, Huddinge University Hospital and Karolinska Institute, Sweden.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1998 May;85(5):509-11. doi: 10.1016/s1079-2104(98)90281-5.
The objective of this study was to retrospectively compare the outcomes of dental implant treatment with and without antibiotic prophylaxis. Two groups of patients with edentulous or partially edentulous maxillas or mandibles (or both) were treated with dental implants. One group, consisting of 147 patients (790 implants), was given prophylaxis with oral phenoxymethylpenicillin; 1 g of antibiotic was administered 1 hour preoperatively, and 1 g was administered every 8 hours for 10 days postoperatively. The other group, consisting of 132 patients (664 implants) was not given any antibiotics preoperatively or postoperatively. There were no significant differences with respect to early and late postoperative infections or with respect to implant survival between the two groups. It appears that antibiotic prophylaxis for routine dental implant surgery offers no advantage for the patient.
本研究的目的是回顾性比较有或没有抗生素预防措施的牙种植治疗结果。两组上颌骨或下颌骨（或两者）无牙或部分无牙的患者接受了牙种植治疗。一组由147名患者（790颗种植体）组成，给予口服苯氧甲基青霉素预防；术前1小时给予1克抗生素，术后每8小时给予1克，持续10天。另一组由132名患者（664颗种植体）组成，术前和术后均未给予任何抗生素。两组在术后早期和晚期感染以及种植体存活率方面没有显著差异。看来常规牙种植手术的抗生素预防对患者没有益处。
