Centrella M, McCarthy T L, Canalis E
Department of Medicine, Saint Francis Hospital & Medical Center, Hartford, CT.
Connect Tissue Res. 1989;20(1-4):267-75. doi: 10.3109/03008208909023896.
Bone formation results from the anabolic and catabolic functions of osteoblasts and osteoclasts within bone. The activities of these cell populations are controlled by complex interacting effects generated by local (bone-derived) and systemic (hormone) growth regulators. One of the more abundant growth regulators produced by bone cells and associated with bone matrix is transforming growth factor beta (TGF-beta). Recent studies indicate that TGF-beta controls the abundance and the biochemical function of osteoblasts and osteoclasts. Also, both TGF-beta production by bone cells, and its effects on bone cell activity, can be influenced by other local growth factors and osteotropic hormones.
骨形成源于骨内成骨细胞和破骨细胞的合成代谢与分解代谢功能。这些细胞群的活动受局部（骨源性）和全身（激素）生长调节因子产生的复杂相互作用影响。骨细胞产生并与骨基质相关的较为丰富的生长调节因子之一是转化生长因子β（TGF-β）。最近的研究表明，TGF-β控制成骨细胞和破骨细胞的数量及生化功能。此外，骨细胞产生的TGF-β及其对骨细胞活性的影响可受其他局部生长因子和促骨激素的影响。
