Chen Ruth R, Mooney David J
Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, USA.
Pharm Res. 2003 Aug;20(8):1103-12. doi: 10.1023/a:1025034925152.
Tissue engineering seeks to replace and regrow damaged or diseased tissues and organs from either cells resident in the surrounding tissue or cells transplanted to the tissue site. The purpose of this review is to present the application of polymeric delivery systems for growth factor delivery in tissue engineering.
Growth factors direct the phenotype of both differentiated and stem cells, and methods used to deliver these molecules include the development of systems to deliver the protein itself, genes encoding the factor, or cells secreting the factor.
Results in animal models and clinical trials indicate that these approaches may be successfully used to promote the regeneration of numerous tissue types.
Controlling the dose, location, and duration of these factors through polymeric delivery strategies will dictate their utility in tissue regeneration.
组织工程旨在利用周围组织中的驻留细胞或移植到组织部位的细胞来替代和再生受损或患病的组织和器官。本综述的目的是介绍聚合物递送系统在组织工程中用于生长因子递送的应用。
生长因子指导分化细胞和干细胞的表型，用于递送这些分子的方法包括开发递送蛋白质本身、编码该因子的基因或分泌该因子的细胞的系统。
动物模型和临床试验的结果表明，这些方法可成功用于促进多种组织类型的再生。
通过聚合物递送策略控制这些因子的剂量、位置和持续时间将决定它们在组织再生中的效用。
