Shrestha B, Marhatha R, Giri A, Jaisi S, Maskey U
Nepal Med Coll J. 2014 Dec;16(2-4):148-51.
Surgical site infection is one of the most common complications following Lower Segment Cesarean Section, which accounts for prolonged hospital stay thereby increasing expense. Prophylactic antibiotics in cesarean section reduces surgical site infection significantly. The best protection is provided when tissue level of antibiotics are adequate before incision, without prejudice to neonatal infectious morbidity. The objective of this study was to compare the incidence of surgical site wound infection with prophylactic antibiotics given before skin incision and after cord clamping following delivery of baby. This was a prospective, hospital based study, in which hundred cases of cesarean deliveries who received antibiotics prophylaxis one hour before the skin incision were compared with another 100 cases where antibiotic was given after cord clamping following delivery of the baby. Surgical site infection occurred in 3% of women who received antibiotics prophylaxis before skin incision as compared to 6% in whom antibiotic was given after cord clamping. It was statistically not significant (p = 0.465).
手术部位感染是下段剖宫产术后最常见的并发症之一，它会导致住院时间延长，从而增加费用。剖宫产术中预防性使用抗生素可显著降低手术部位感染。当切口前组织中的抗生素水平足够时，能提供最佳保护，且不影响新生儿感染发病率。本研究的目的是比较在婴儿娩出后皮肤切口前和脐带结扎后给予预防性抗生素的情况下手术部位伤口感染的发生率。这是一项基于医院的前瞻性研究，将100例在皮肤切口前1小时接受抗生素预防的剖宫产病例与另外100例在婴儿娩出后脐带结扎后给予抗生素的病例进行比较。在皮肤切口前接受抗生素预防的女性中，手术部位感染发生率为3%，而在脐带结扎后给予抗生素的女性中这一发生率为6%。差异无统计学意义（p = 0.465）。
