Adhikari N, Shah P K, Acharya G, Vaidya K M
Nepal Med Coll J. 2014 Dec;16(2-4):161-4.
Neonatal Sepsis is one of the most common reasons for admission to neonatal units in developing countries. It is also a major cause of mortality in both developed and developing countries. Identification of the common bacteria and risk factors causing such infections and their susceptibility patterns will provide necessary information for timely intervention. This study was carried out to determine the bacteriological profile and associated risk factors of neonatal sepsis in Paropakar Maternity and Women's hospital. A cross-sectional prospective study was conducted among neonates suspected of neonatal sepsis. Blood culture was performed and organisms were identified and antibiotic susceptibility was carried out with standard microbiological methods. Data were analysed by using SPSS. Ver. 16 software. The positive yield of blood culture was 21%. The most common isolates were Staphylococcus epidermidis, E. coli, Staphylococcus aureus, Klebsiella pneumoniae and Pseudomonas spp. In Antibiotic susceptibility pattern Gentamycin showed the highest sensitivity to all types of isolated organisms. Vancomycin sensitivity was highest for Gram positive organism and Ciprofloxacin was most effective for Gram negative organisms isolated. Ampicillin and Amoxycillin were the least effective drug. Multiple drug resistance was observed in 77.15% of isolates. Prematurity, low birth weight and maternal pyrexia before delivery were found to be strongly associated with neonatal sepsis. Gram positive organisms were more prevalent than gram negative organisms.
新生儿败血症是发展中国家新生儿入住新生儿病房最常见的原因之一。它也是发达国家和发展中国家死亡的主要原因。确定引起此类感染的常见细菌、危险因素及其药敏模式将为及时干预提供必要信息。本研究旨在确定帕罗帕卡尔妇产医院新生儿败血症的细菌学特征及相关危险因素。对疑似新生儿败血症的新生儿进行了一项横断面前瞻性研究。进行血培养，鉴定微生物，并采用标准微生物学方法进行药敏试验。使用SPSS 16.0软件对数据进行分析。血培养阳性率为21%。最常见的分离株为表皮葡萄球菌、大肠杆菌、金黄色葡萄球菌、肺炎克雷伯菌和假单胞菌属。在药敏模式中，庆大霉素对所有类型的分离菌显示出最高的敏感性。万古霉素对革兰氏阳性菌敏感性最高，环丙沙星对分离出的革兰氏阴性菌最有效。氨苄西林和阿莫西林是最无效的药物。77.15%的分离株观察到多重耐药。早产、低出生体重和分娩前母亲发热与新生儿败血症密切相关。革兰氏阳性菌比革兰氏阴性菌更普遍。
